南方科技大学知识苑(SUSTech KC): FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function

题名	FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function
作者	Zeng, Yonglian 1,2; Guo, Zhenya 1; Hu, Zhigao 1; Liu, Mingjiang 1; Chen, Yubing 1; Chen, Shilian 1; Peng, Bo 1; Zhang, Peng 1; Wu, Zhan 1; Luo, Hongliang 1; Zhong, Fudi 1; Jiang, Keqing 1; Lu, Yi3 ; Yuan, Guandou 1; He, Songqing 1
通讯作者	Lu, Yi; Yuan, Guandou; He, Songqing
发表日期	2020-05
DOI	10.1016/j.biopha.2020.110029
发表期刊	BIOMEDICINE & PHARMACOTHERAPY 影响因子和分区
ISSN	0753-3322
EISSN	1950-6007
卷号	125
摘要	Faciogenital Dysplasia 1 (FGD1) has been involved in a variety of biological processes, including cytoskeleton restructuring, cell morphology, cell cycle progression, and cell polarity. Abnormal expression of FGD1 was also identified in several types of cancers, indicating its critical role in the development of cancers. However, little is known about the role of FGD1 in hepatocellular carcinoma (HCC). In this study, the expression of FGD1 in HCC was mined with the RNA sequencing data from the cancer genome atlas. By over-expressing or knocking down of FGD1, the effects of FGD1 on the malignant behavior of HCC were evaluated both in vitro and in vivo. We find that FGD1 is up-regulated in HCC and correlated with the development and prognosis of HCC. By over-expressing or knocking down of FGD1, the effects of FGD1 on the malignant behavior of HCC were evaluated both in vitro and in vivo. Knockdown of FGD1 remarkably inhibits the malignant behaviors and causes morphological disorder of pseudopodia, autophagy inhibition and mitochondrial dyfunction in HCC cells. Further investigation shows that Cdc42, a Rho GTPase, plays a role in these processes. Overexpression of FGD1 significantly promotes the oncogenic properties of HCC cells. Collectively, these findings reveal that FGD1 exhibits oncogenic properties in HCC through regulating cell morphology, autophagy and mitochondrial function, suggesting that FGD1 may serve as a potential therapeutic target for HCC.
关键词	Faciogenital Dysplasia 1 Hepatocellular carcinoma Metastasis Autophagy
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	111 Projects[D17011]
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号	WOS:000519520000051
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
来源库	Web of Science
引用统计	被引频次[WOS]：13
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/104373
专题	南方科技大学医学院
作者单位	1.Guangxi Med Univ, Affiliated Hosp 1, Div Hepatobiliary Surg, 6 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China 2.Guangxi Med Univ, Basic Med Sch, Nanning 530021, Guangxi, Peoples R China 3.Southern Univ Sci & Technol, Sch Med, 1088 Xili Xueyuan Ave, Shenzhen 518055, Guangdong, Peoples R China
通讯作者单位	南方科技大学医学院
推荐引用方式 GB/T 7714	Zeng, Yonglian,Guo, Zhenya,Hu, Zhigao,et al. FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function[J]. BIOMEDICINE & PHARMACOTHERAPY,2020,125.
APA	Zeng, Yonglian.,Guo, Zhenya.,Hu, Zhigao.,Liu, Mingjiang.,Chen, Yubing.,...&He, Songqing.(2020).FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function.BIOMEDICINE & PHARMACOTHERAPY,125.
MLA	Zeng, Yonglian,et al."FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function".BIOMEDICINE & PHARMACOTHERAPY 125(2020).