Associations of long-term exposure to ambient PM2.5 with mortality in Chinese adults: A pooled analysis of cohorts in the China-PAR project

Yang, Xueli1,2; Liang, Fengchao1; Li, Jianxin1; Chen, Jichun1; Liu, Fangchao1; Huang, Keyong1; Cao, Jie1; Chen, Shufeng1; Xiao, Qingyang3; Liu, Xiaoqing4; Shen, Chong5; Yu, Ling6; Lu, Fanghong7; Wu, Xianping8; Wu, Xigui1; Li, Ying1; Zhao, Liancheng1; Hu, Dongsheng9; Huang, Jianfeng1; Lu, Xiangfeng1; Liu, Yang10; Gu, Dongfeng1,11

2020

10.1016/j.envint.2020.105589

Environment International   影响因子和分区

18736750

1873-6750

Background: The concentration-response relationship between mortality and long-term exposure to fine particulate matter (PM2.5) has not been fully elucidated, especially at high levels of PM2.5 concentrations. Objective: We aimed to evaluate chronic effects of ambient PM2.5 exposure on deaths among Chinese adults in high-exposure settings. Methods: Participants of the Prediction for Atherosclerotic cardiovascular disease Risk in China (China-PAR) project were included from four prospective cohorts among Chinese adults aged ≥18 years old. The overall follow-up rate of the four cohorts was 93.4% until the recent follow-up survey that ended in 2015. The average of satellite-based PM2.5 concentrations during 2000–2015 at 1-km spatial resolution was assigned to each participant according to individual residence addresses. Based on the pooled analysis of individual data from the four cohorts, a Cox proportional hazards model was used to estimate the hazard ratio (HR) and corresponding 95% confidence intervals (95% CIs) for the association of PM2.5 exposure with mortality after multivariate adjustment. Results: A total of 116,821 participants were eligible in the final analysis. During a mean of 7.7 years of follow-up, 6,395 non-accidental deaths and 2,507 cardio-metabolic deaths occurred. The mean of PM2.5 concentration was 64.9 μg/m³ ranging from 31.2 μg/m³ to 97.0 μg/m³. For each 10 μg/m³ increment in PM2.5, the HR was 1.11 (95% CI: 1.08–1.14) for non-accidental mortality and 1.22 (95% CI: 1.16–1.27) for cardio-metabolic mortality. In addition, a weak exponential curve for the concentration-response association between mortality and PM2.5 was observed among Chinese adults. Conclusions: Our study provided important evidence of the long-term effects of PM2.5 exposure on deaths among Chinese adults. The findings expand our knowledge on concentration-response relationship in high-exposure environments, which is essential to address the urgent challenge of reducing the disease burden attributable to PM2.5 exposure in rapidly industrializing countries such as China.
© 2020

Satellite-based PM2.5 Long-term exposure Cohort study Mortality Concentration-response relationship

EI ; SCI

英语

其他

National Basic Research Program of China (973 Program)[2016YFC0206503] ; Chinese Academy of Medical Sciences[2017-I2M-1-004] ; California Institute of Technology[1588347]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000522749900012

Elsevier Ltd

20201008264504

Hazards ; Metabolism

Accidents and Accident Prevention:914.1

ENVIRONMENT/ECOLOGY

EV Compendex

1.Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; 100037, China
2.Tianjin Key Laboratory of Environment, Nutrition and Public Health; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin; 300070, China
3.School of Environment, Tsinghua University, Beijing; 100084, China
4.Division of Epidemiology, Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou; 510080, China
5.Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing; 211166, China
6.Department of Cardiology, Fujian Provincial Hospital, Fuzhou; 350014, China
7.Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan; 250062, China
8.Sichuan Center for Disease Control and Prevention, Chengdu; 610041, China
9.Department of Prevention Medicine, Shenzhen University School of Medicine, Shenzhen; 518060, China
10.Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta; GA; 30322, United States
11.Medical School, Southern University of Science and Technology, Shenzhen; 518055, China

Yang, Xueli,Liang, Fengchao,Li, Jianxin,et al. Associations of long-term exposure to ambient PM2.5 with mortality in Chinese adults: A pooled analysis of cohorts in the China-PAR project[J]. Environment International,2020,138.

Yang, Xueli.,Liang, Fengchao.,Li, Jianxin.,Chen, Jichun.,Liu, Fangchao.,...&Gu, Dongfeng.(2020).Associations of long-term exposure to ambient PM2.5 with mortality in Chinese adults: A pooled analysis of cohorts in the China-PAR project.Environment International,138.

Yang, Xueli,et al."Associations of long-term exposure to ambient PM2.5 with mortality in Chinese adults: A pooled analysis of cohorts in the China-PAR project".Environment International 138(2020).