Highly adhesive carbon quantum dots from biogenic amines for prevention of biofilm formation

Jian, Hong-Jyuan1; Yu, Jiantao2; Li, Yu-Jia3; Unnikrishnan, Binesh4; Huang, Yu-Fen3; Luo, Li-Jyuan1; Hui-Kang Ma, David5; Harroun, Scott G.6; Chang, Huan-Tsung7; Lin, Han-Jia4; Lai, Jui-Yang1,5,8; Huang, Chih-Ching4,9,10

2020

10.1016/j.cej.2019.123913

CHEMICAL ENGINEERING JOURNAL   影响因子和分区

1385-8947

1873-3212

We demonstrate the synthesis of antibacterial carbon quantum dots (CQDs) through a one-step pyrolysis of biogenic polyamine (PA) and dopamine (DA) mixture. SPM/DA-CQDs synthesized from DA combined with spermine (SPM) exhibit effective antibacterial activity and high adhesion properties on glass and surfaces of polymeric contact lens material. The antimicrobial activity of SPM/DA-CQDs is primarily due to their ability to disrupt the bacterial membrane, and they possess wide spectrum antimicrobial activity against Gram-negative bacteria (Escherichia coli, Salmonella enterica serovar Enteritidis, and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and its multidrug-resistant strain, methicillin-resistant S. aureus). The minimal inhibitory concentration (MIC) of SPM/DA-CQDs against the tested bacteria was >17-fold and >7-fold lower than those of CQDs prepared solely from spermine and dopamine, respectively. The great biocompatibility of our SPM/DA-CQDs is revealed from the in vitro cytotoxicity and hemolysis assays and in vivo evaluation of morphological and physiological changes of rabbit corneas. We further prepared SPM/DA-CQDs-coated coverslips and contact lenses, which display excellent stability and antibiofilm properties. Moreover, in vivo tests show that SPM/DA-CQDs suppress bacterial keratitis (BK) formation in a corneal-injured rabbit model. Our results indicate that SPM/DA-CQDs have great potential as a coating material for inhibition of biofilm formation on contact lenses, and broadly to protect medical devices from contamination.
© 2019 Elsevier B.V.

Polyamines Dopamine Carbon quantum dots Antibiofilm Contact lenses Bacterial keratitis

EI ; SCI

英语

其他

Ministry of Science and Technology, Taiwan[]

Engineering

Engineering, Environmental ; Engineering, Chemical

WOS:000548614900005

Elsevier B.V.

20200408071598

Adhesives ; Biocompatibility ; Biofilms ; Carbon ; Contact lenses ; Escherichia coli ; Nanocrystals ; Neurophysiology ; Physiological models ; Salmonella ; Semiconductor quantum dots

Bioengineering and Biology:461 ; Biomaterials (including synthetics):462.5 ; Semiconductor Devices and Integrated Circuits:714.2 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Organic Compounds:804.1

ENGINEERING

EV Compendex

1.Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan; 33302, Taiwan
2.Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen; Guangdong; 518055, China
3.Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu; 30013, Taiwan
4.Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung; 20224, Taiwan
5.Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou; Taoyuan; 33305, Taiwan
6.Department of Chemistry, Université de Montréal, Montréal; Québec; H3C 3J7, Canada
7.Department of Chemistry, National Taiwan University, Taipei; 10617, Taiwan
8.Department of Materials Engineering, Ming Chi University of Technology, New Taipei City; 24301, Taiwan
9.Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung; 20224, Taiwan
10.School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung; 80708, Taiwan

Jian, Hong-Jyuan,Yu, Jiantao,Li, Yu-Jia,et al. Highly adhesive carbon quantum dots from biogenic amines for prevention of biofilm formation[J]. CHEMICAL ENGINEERING JOURNAL,2020,386.

Jian, Hong-Jyuan.,Yu, Jiantao.,Li, Yu-Jia.,Unnikrishnan, Binesh.,Huang, Yu-Fen.,...&Huang, Chih-Ching.(2020).Highly adhesive carbon quantum dots from biogenic amines for prevention of biofilm formation.CHEMICAL ENGINEERING JOURNAL,386.

Jian, Hong-Jyuan,et al."Highly adhesive carbon quantum dots from biogenic amines for prevention of biofilm formation".CHEMICAL ENGINEERING JOURNAL 386(2020).