Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

Zhou, Kai1,2; Xiao, Tingting3; David, Sophia4; Wang, Qin3; Zhou, Yanzi3; Guo, Lihua3; Aanensen, David4; Holt, Kathryn E.5,6; Thomson, Nicholas R.6,7; Grundmann, Hajo8; Shen, Ping3; Xiao, Yonghong3

2020-02

10.3201/eid2602.190594

EMERGING INFECTIOUS DISEASES   影响因子和分区

1080-6040

1080-6059

We aimed to clarify the epidemiologic and clinical importance of evolutionary events that occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP causing bloodstream infections in a tertiary hospital in China during 2013-2017. We detected a sub-clonal shift in the dominant clone sequence type (ST) 11 CRKP in which the previously prevalent capsular loci (KL) 47 had been replaced by KL64 since 2016. Patients infected with ST11-KL64 CRKP had a significantly higher 30-day mortality rate than other CRKP-infected patients. Enhanced virulence was further evidenced by phenotypic tests. Phylogenetic reconstruction demonstrated that ST11-KL64 is derived from an ST11-KL47-like ancestor through recombination. We identified a pLVPK-like virulence plasmid carrying rmpA and peg-344 in ST11-KL64 exclusively from 2016 onward. The pLVPK-like-positive ST11-KL64 isolates exhibited enhanced environmental survival. Retrospective screening of a national collection identified ST11-KL64 in multiple regions. Targeted surveillance of this high-risk CRKP clone is urgently needed.

SCI

英语

第一

National Natural Science Foundation of China[81702045] ; National Natural Science Foundation of China[81361138021]

Immunology ; Infectious Diseases

Immunology ; Infectious Diseases

WOS:000510436500013

CENTERS DISEASE CONTROL & PREVENTION

IMMUNOLOGY

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China
3.Zhejiang Univ, Hangzhou, Peoples R China
4.Ctr Genom Pathogen Surveillance, Cambridge, England
5.Univ Melbourne, Melbourne, Vic, Australia
6.London Sch Hyg & Trop Med, London, England
7.Wellcome Trust Sanger Ctr, Cambridge, England
8.Univ Freiburg, Freiburg, Germany

Zhou, Kai,Xiao, Tingting,David, Sophia,et al. Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China[J]. EMERGING INFECTIOUS DISEASES,2020,26(2):289-297.

Zhou, Kai.,Xiao, Tingting.,David, Sophia.,Wang, Qin.,Zhou, Yanzi.,...&Xiao, Yonghong.(2020).Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China.EMERGING INFECTIOUS DISEASES,26(2),289-297.

Zhou, Kai,et al."Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China".EMERGING INFECTIOUS DISEASES 26.2(2020):289-297.