Prognostic significance of common preoperative laboratory variables in penile squamous cell carcinoma

Li, Zaishang1,2,3,4,5; Li, Xueying6; Zhang, Xueqi1,2; Chen, Peng7; Wang, Bin8; Chen, Xiaofeng9; Han, Hui3,4,5; Zhou, Fangjian3,4,5

2020-01

10.1111/iju.14137

INTERNATIONAL JOURNAL OF UROLOGY   影响因子和分区

0919-8172

1442-2042

Objective To investigate the predictive value of common preoperative laboratory variables in patients undergoing bilateral inguinal lymph node dissection surgery for penile squamous cell carcinoma. Methods We retrospectively analyzed the records of 228 patients who had bilateral inguinal lymph node dissection for penile squamous cell carcinoma to assess the following clinical factors: preoperative laboratory measurements, white blood cell count, platelet count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, serum calcium, total protein, globulin, pathological factors and survival rates after surgery. Results The percentage of positive lymph nodes was 52.6%. Univariate analysis showed that the tumor stage and grade, the presence of metastasis, white blood cell count, platelet count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and globulin were significantly associated with the disease-specific survival (all P < 0.05). At multivariate analysis, only the neutrophil-to-lymphocyte ratio had an independent effect (hazard ratio 2.131; P = 0.035). The predictive accuracy of the neutrophil-to-lymphocyte ratio was the best among the laboratory variables. The predictive accuracy of the basic pathological factors was significantly increased by incorporating the neutrophil-to-lymphocyte ratio prognosticator. Conclusion The neutrophil-to-lymphocyte ratio before inguinal lymph node dissection might be useful for predicting the prognosis of patients with penile squamous cell carcinoma.

inflammation lymph node metastasis penile neoplasms prognosis survival rate

SCI

英语

第一

Shenzhen Healthcare Research Project[SZLY2018010]

Urology & Nephrology

Urology & Nephrology

WOS:000506524900016

WILEY

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Dept Urol, Shenzhen, Peoples R China
2.Jinan Univ, Clin Coll 2, Dept Urol, Shenzhen, Peoples R China
3.Sun Yat Sen Univ, Dept Urol, Ctr Canc, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China
4.State Key Lab Oncol Southern China, Guangzhou, Peoples R China
5.Collaborat Innovat Ctr Canc Med, Guangzhou, Peoples R China
6.Sun Yat Sen Univ, Hosp 7, Dept Med Oncol, Shenzhen, Peoples R China
7.Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Urol, Urumqi, Peoples R China
8.Guangzhou Med Univ, Ctr Canc, Dept Urol, Guangzhou, Peoples R China
9.First Peoples Hosp Chenzhou, Dept Urol, Chenzhou, Peoples R China

Li, Zaishang,Li, Xueying,Zhang, Xueqi,et al. Prognostic significance of common preoperative laboratory variables in penile squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF UROLOGY,2020,27(1):76-82.

Li, Zaishang.,Li, Xueying.,Zhang, Xueqi.,Chen, Peng.,Wang, Bin.,...&Zhou, Fangjian.(2020).Prognostic significance of common preoperative laboratory variables in penile squamous cell carcinoma.INTERNATIONAL JOURNAL OF UROLOGY,27(1),76-82.

Li, Zaishang,et al."Prognostic significance of common preoperative laboratory variables in penile squamous cell carcinoma".INTERNATIONAL JOURNAL OF UROLOGY 27.1(2020):76-82.