| 题名 | Follicular helper T cells in type 1 diabetes |
| 作者 | |
| 通讯作者 | Yu, Di; Zhou, Zhiguang; Jia, Lijing |
| 发表日期 | 2020-01
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| DOI | |
| 发表期刊 | |
| ISSN | 0892-6638
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| EISSN | 1530-6860
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| 卷号 | 34期号:1页码:30-40 |
| 摘要 | Type 1 diabetes (T1D) is an autoimmune disease caused by the dysfunction of immune system and consequently the destruction of insulin-producing beta cells. In past decades, numerous studies have uncovered that CD4(+) T cell subsets are critical in the pathogenesis of T1D, manifesting that type 1 T helper (Th1) and Th17 cells are pathogenic, while regulatory T (Treg) cells and Th2 cells are protective. More recently, the pathogenic role of another subset, follicular helper T (Tfh) cells that essentially regulate germinal center (GC) formation and humoral responses, has also been demonstrated in T1D and many other autoimmune diseases. In this review, we summarize the evidence for the aberrant differentiation and function of Tfh cells in T1D, and also discuss the underlying mechanisms. A better understanding on the pathogenic role of Tfh cells in T1D will inspire the design of potential therapeutic strategies to target this subset in the future. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | Central South University[2018zzts921]
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| WOS研究方向 | Biochemistry & Molecular Biology
; Life Sciences & Biomedicine - Other Topics
; Cell Biology
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| WOS类目 | Biochemistry & Molecular Biology
; Biology
; Cell Biology
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| WOS记录号 | WOS:000507308900004
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| 出版者 | |
| ESI学科分类 | BIOLOGY & BIOCHEMISTRY
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：24
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/104566 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Cent S Univ, Dept Metab & Endocrinol, Xiangya Hosp 2, Changsha, Peoples R China 2.Cent S Univ, Natl Clin Res Ctr Metab Dis, Key Lab Diabet Immunol, Minist Educ, Changsha, Peoples R China 3.Southern Univ Sci & Technol, Dept Endocrinol, Shenzhen Peoples Hosp, Jinan Univ,Clin Med Coll 2,Affiliated Hosp 1, Shenzhen, Peoples R China 4.Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia 5.Shandong Acad Sci, Shandong Anal & Test Ctr, Jinan, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Renji Hosp, China Australia Ctr Personalised Immunol, Shanghai, Peoples R China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Shao, Feng,Zheng, Peilin,Yu, Di,et al. Follicular helper T cells in type 1 diabetes[J]. FASEB JOURNAL,2020,34(1):30-40.
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| APA |
Shao, Feng,Zheng, Peilin,Yu, Di,Zhou, Zhiguang,&Jia, Lijing.(2020).Follicular helper T cells in type 1 diabetes.FASEB JOURNAL,34(1),30-40.
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| MLA |
Shao, Feng,et al."Follicular helper T cells in type 1 diabetes".FASEB JOURNAL 34.1(2020):30-40.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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