Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Jiang, Yizhou1,2,3; Yan, Fengxia4; Feng, Zhongping5; Lazarovici, Philip6; Zheng, Wenhua1,2

2020-01

10.3390/cells9010100

Cells   影响因子和分区

2073-4409

2073-4409

Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal. However, the molecular mechanisms by which DR confers benefits on longevity were not yet fully elucidated. The forkhead box O transcription factors (FOXOs), identified as downstream regulators of the insulin/IGF-1 signaling pathway, control the expression of many genes regulating crucial biological processes such as metabolic homeostasis, redox balance, stress response and cell viability and proliferation. The activity of FOXOs is also mediated by AMP-activated protein kinase (AMPK), sirtuins and the mammalian target of rapamycin (mTOR). Therefore, the FOXO-related pathways form a complex network critical for coordinating a response to environmental fluctuations in order to maintain cellular homeostasis and to support physiological aging. In this review, we will focus on the role of FOXOs in different DR interventions. As different DR regimens or calorie (energy) restriction mimetics (CRMs) can elicit both distinct and overlapped DR-related signaling pathways, the benefits of DR may be maximized by combining diverse forms of interventions. In addition, a better understanding of the precise role of FOXOs in different mechanistic aspects of DR response would provide clear cellular and molecular insights on DR-induced increase of lifespan and health-span.

FOXO dietary restriction insulin/IGF-1 signaling pathway AMPK sirtuins mTOR longevity calorie restriction mimetics

SCI ; SSCI

英语

其他

FHS Internal Collaboration Proposals 2017, University of Macau[MYRG2016-00052-FHS] ; FHS Internal Collaboration Proposals 2017, University of Macau[MYRG2018-00134-FHS]

Cell Biology

Cell Biology

WOS:000515398200100

MDPI

Web of Science

1.Univ Macau, Fac Hlth Sci, Ctr Reprod Dev & Aging, Macau 999078, Peoples R China
2.Univ Macau, Fac Hlth Sci, Inst Translat Med, Macau 999078, Peoples R China
3.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China
4.Jinan Univ, Sch Med Sci, Guangzhou 510080, Peoples R China
5.Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada
6.Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, IL-91120 Jerusalem, Israel

Jiang, Yizhou,Yan, Fengxia,Feng, Zhongping,et al. Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction[J]. Cells,2020,9(1).

Jiang, Yizhou,Yan, Fengxia,Feng, Zhongping,Lazarovici, Philip,&Zheng, Wenhua.(2020).Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction.Cells,9(1).

Jiang, Yizhou,et al."Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction".Cells 9.1(2020).