| 题名 | Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer |
| 作者 | |
| 通讯作者 | Chen, Tianfeng; Zhang, Han |
| 发表日期 | 2020-01
|
| DOI | |
| 发表期刊 | |
| ISSN | 1616-301X
|
| EISSN | 1616-3028
|
| 卷号 | 30期号:4 |
| 摘要 | Nanoparticulate chemotherapeutics hold great potential for inducing reactive oxygen species (ROS) overproduction and exerting antihypoxic effects for efficient cancer radiotherapy. However, previous strategies for designing smart radiosensitizers necessitate the multistep incorporation of nanomaterials to achieve valuable radiosensitive outcomes, which causes unpredictable safety issues including poor decomposition and undefined biotransformations. Ultrathin antimonene nanoparticles (AMNPs) are demonstrated as new radiosensitizers that achieve an efficient radiochemotherapeutic effect through the induction of a strong oxidative stress response and their significantly high radiotoxicity in vivo. Analyzing the irradiation process of AMNPs indicates that irradiation accelerates photoelectron generation and the valence transition to toxic Sb2O3, leading to cancer cell apoptosis and S-phase arrest. The tumor regression activity and concealed biotoxicity of the AMNPs in a melanoma mouse model enhance the applicability of antimonene to overcoming radioresistance by increasing ROS generation and normoxia. This new technology can extend the applications of antimonene as an effective radiosensitizer and can promote its clinical translation for tunable and effective radiosensitization in the future. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 其他
|
| WOS研究方向 | Chemistry
; Science & Technology - Other Topics
; Materials Science
; Physics
|
| WOS类目 | Chemistry, Multidisciplinary
; Chemistry, Physical
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
; Physics, Applied
; Physics, Condensed Matter
|
| WOS记录号 | WOS:000509522500043
|
| 出版者 | |
| ESI学科分类 | MATERIALS SCIENCE
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：62
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/104634 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Shenzhen Univ, Inst Microscale Optoelect, Minist Educ, Int Collaborat Lab 2D Mat Optoelect Sci & Technol, Shenzhen 518060, Peoples R China 2.Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden 3.Jinan Univ, Affiliated Hosp 1, Guangzhou 510632, Peoples R China 4.Jinan Univ, Dept Chem, Guangzhou 510632, Peoples R China 5.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ,Clin Med Coll 2, Dept Gastrointestinal Surg,Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Duo, Yanhong,Huang, Yanyu,Liang, Weiyuan,et al. Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer[J]. ADVANCED FUNCTIONAL MATERIALS,2020,30(4).
|
| APA |
Duo, Yanhong.,Huang, Yanyu.,Liang, Weiyuan.,Yuan, Riming.,Li, Yang.,...&Zhang, Han.(2020).Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer.ADVANCED FUNCTIONAL MATERIALS,30(4).
|
| MLA |
Duo, Yanhong,et al."Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer".ADVANCED FUNCTIONAL MATERIALS 30.4(2020).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
;
修改评论