Effect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis

Chen, Peifen1; Jiang, Jihong2; Zhang, Yunhe3; Li, Guobao4; Qiu, Zhihui5; Levy, Mitchell M.6; Hu, Baoji2

2020-02-17

10.1186/s12890-020-1065-6

BMC Pulmonary Medicine   影响因子和分区

1471-2466

Background Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on the duration of mechanical ventilation remains unclear. The present study was conducted to review the extant literature in DEX and determine its influence on ventilation time in adult septic patients. Methods Databases of PubMed, Cochrane, and EMBASE were applied till 20th January 2019 without language restriction. The searching strategy as following: sepsis OR septic AND mechanical ventilation AND dexmedetomidine. Two authors screened titles, abstracts, and even articles to meet the including criterion independently. In addition, references of related articles or reviews were also referred. Data was recorded in a table and analyzed using the software of Review Manager 5.0. Results Four studies with a total of 349 patients were included. Three trials with 267 patients revealed the effect of DEX on duration of mechanical ventilation, two trials with 264 patients on ventilator-free days and four trials with 334 patients on 28-day mortality. The analyzed results indicated that DEX was not associated with significantly different durations of mechanical ventilation (MD 0.65, 95% CI, - 0.13 to 1.42, P = 0.10). However, there were significant differences in ventilator-free days (MD 3.57, 95% CI, 0.26 to 6.89, P = 0.03) and 28-day mortality (RR 0.61, 95% CI, 0.49 to 0.94, P = 0.02) in the septic patients. Conclusion Administration of DEX for sedation in septic patients was not associated with the duration of mechanical ventilation, but it increased the ventilator-free days and reduced 28-day mortality.

Sepsis Duration of mechanical ventilation Dexmedetomidine Systematic review and meta-analysis

SCI

英语

第一

National Natural Science Foundation of China[81701885]

Respiratory System

Respiratory System

WOS:000517156100001

BMC

Web of Science

1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Resp Dis, Affiliated Hosp 2, Shenzhen 518112, Guangdong, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Anesthesiol, Sch Med, Shanghai, Peoples R China
3.Tongji Univ, Shanghai East Hosp, Dept Ctr ICU, Sch Med, Shanghai, Peoples R China
4.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Pulm Med 3, Affiliated Hosp 2, Shenzhen, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Affiliated Hosp 2, Gastroscopy Room, Shenzhen, Guangdong, Peoples R China
6.Brown Univ, Dept Med, Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USA

Chen, Peifen,Jiang, Jihong,Zhang, Yunhe,et al. Effect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis[J]. BMC Pulmonary Medicine,2020,20(1).

Chen, Peifen.,Jiang, Jihong.,Zhang, Yunhe.,Li, Guobao.,Qiu, Zhihui.,...&Hu, Baoji.(2020).Effect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis.BMC Pulmonary Medicine,20(1).

Chen, Peifen,et al."Effect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis".BMC Pulmonary Medicine 20.1(2020).