| 题名 | Strategies for the CRISPR-Based Therapeutics |
| 作者 | |
| 通讯作者 | Li, Bin; Niu, Yuyu; Ji, Weizhi; Dong, Yizhou |
| 发表日期 | 2020-01
|
| DOI | |
| 发表期刊 | |
| ISSN | 0165-6147
|
| EISSN | 1873-3735
|
| 卷号 | 41期号:1页码:55-65 |
| 摘要 | The CRISPR (clustered regularly interspaced short palindromic repeats)-based genome editing technology is an emerging RNA-guided nuclease system initially identified from the microbial adaptive immune systems. In recent years, the CRISPR system has been reprogrammed to target specific regions of the eukaryotic genome and has become a powerful tool for genetic engineering. Researchers have explored many approaches to improve the genome editing activity of the CRISPR-Cas system and deliver its components both ex vivo and in vivo. Moreover, these strategies have been applied to genome editing in preclinical research and clinical trials. In this review, we focus on representative strategies for regulation and delivery of the CRISPR-Cas system, and outline current therapeutic applications in their clinical translation. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 通讯
|
| 资助项目 | National Key Research and Development Program[2016YFA0101401]
; National Key Research and Development Program[R35GM119679]
|
| WOS研究方向 | Pharmacology & Pharmacy
|
| WOS类目 | Pharmacology & Pharmacy
|
| WOS记录号 | WOS:000508831100006
|
| 出版者 | |
| ESI学科分类 | PHARMACOLOGY & TOXICOLOGY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：35
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/104646 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Infect Dis,Shenzhen Peoples Hosp,Clin Med Co, Shenzhen 518020, Peoples R China 2.Kunming Univ Sci & Technol, Inst Primate Translat Med, Yunnan Key Lab Primate Biomed Res, Kunming 650500, Yunnan, Peoples R China 3.Ohio State Univ, Coll Pharm, Div Pharmaceut & Pharmacol, Columbus, OH 43210 USA |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Li, Bin,Niu, Yuyu,Ji, Weizhi,et al. Strategies for the CRISPR-Based Therapeutics[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2020,41(1):55-65.
|
| APA |
Li, Bin,Niu, Yuyu,Ji, Weizhi,&Dong, Yizhou.(2020).Strategies for the CRISPR-Based Therapeutics.TRENDS IN PHARMACOLOGICAL SCIENCES,41(1),55-65.
|
| MLA |
Li, Bin,et al."Strategies for the CRISPR-Based Therapeutics".TRENDS IN PHARMACOLOGICAL SCIENCES 41.1(2020):55-65.
|
| 条目包含的文件 | 条目无相关文件。 | |||||
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