Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

Zhang, Xiao1,2; He, Shuqing1,3; Ding, Bingbing1; Qu, Chunrong1; Zhang, Qing1; Chen, Hao1; Sun, Yu1; Fang, Hanyi2; Long, Yu2; Zhang, Ruiping4; Lan, Xiaoli2; Cheng, Zhen1

2020-04

10.1016/j.cej.2019.123959

CHEMICAL ENGINEERING JOURNAL   影响因子和分区

1385-8947

1873-3212

With the attractive characteristics of low toxicity, narrow emission spectra, long fluorescence lifetime, and no photobleaching, rare-earth doped nanoparticles (RENPs) have become promising imaging nanoplatforms in the second near-infrared window (NIR-II, 1000-1700 nm). Many studies have been devoted to different surface modification strategies of RENPs to achieve good NIR-II tumor imaging property. However, the tumor imaging efficiency of these approaches remains disappointing. Herein, two methods were pursued to modify RENPs with either polyethylene glycol (PEG) or cancer-cell-membrane to generate PEGylated-RENPs and cancer-cell-membrane camouflaged RENPs (CC-RENPs), respectively. This study demonstrated that cancer-cell-membrane coating of RENPs greatly improved tumor imaging performance in NIR-II window than PEG coating. Besides, CC-RENPs uptakes in liver and spleen significantly decreased. Importantly, CC-RENPs was found to be capable to aid us to pursue precise resection of the tumor. In conclusion, CC-RENPs are capable of targeting tumors and show high tumor NIR-II imaging quality. They are highly promising nanomaterials for future medical applications.

NIR-II imaging Rare-earth doped nanoparticles Cancer cell membrane Tumor imaging Surgery navigation

SCI ; EI

英语

其他

China Scholarship Council[201706160068]

Engineering

Engineering, Environmental ; Engineering, Chemical

WOS:000507465200033

ELSEVIER SCIENCE SA

20200608124015

Cells ; Cytology ; Rare earths ; Membranes ; Coatings ; Emission spectroscopy ; Photobleaching ; Nanoparticles ; Diseases ; Medical applications ; Infrared devices ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemistry:801 ; Inorganic Compounds:804.2 ; Coating Materials:813.2 ; Solid State Physics:933 ; Materials Science:951

ENGINEERING

Web of Science

1.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Mol Imaging Program Stanford,Bio X Program, Stanford, CA 94305 USA
2.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nucl Med, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China
3.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Dept Biomed Engn, Shenzhen 518055, Peoples R China
4.Shanxi Med Univ, Affiliated Tumor Hosp, Taiyuan 030013, Shanxi, Peoples R China

Zhang, Xiao,He, Shuqing,Ding, Bingbing,et al. Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window[J]. CHEMICAL ENGINEERING JOURNAL,2020,385.

Zhang, Xiao.,He, Shuqing.,Ding, Bingbing.,Qu, Chunrong.,Zhang, Qing.,...&Cheng, Zhen.(2020).Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window.CHEMICAL ENGINEERING JOURNAL,385.

Zhang, Xiao,et al."Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window".CHEMICAL ENGINEERING JOURNAL 385(2020).