Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice

Liu, Yang1,2; Fang, Shu1; Liu, Li-Man1; Zhu, Yan1; Li, Chang-Ri1,3; Chen, Kaitian1,4; Zhao, Hong-Bo1

2020-01-19

10.1016/j.neulet.2019.134705

NEUROSCIENCE LETTERS   影响因子和分区

0304-3940

1872-7972

Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive loss of memory and cognitive decline. Over the last decade, it has been found that defects in sensory systems could be highly associated with AD. Hearing is an important neural sense. However, little is known about hearing functional changes in AD. In this study, APP/PS1 AD mice (Jackson Lab: Stack No. 004462) were used. Hearing function was assessed by auditory brainstem response (ABR), distortion product otoacoustic emission (DPOAE), and cochlear microphonics (CM) recordings. Wild-type (WT) littermates served as control. We found that APP/PS1 AD mice measured as ABR threshold had hearing loss. The hearing loss appeared at high frequency as early as 2 months old, prior to the reported occurrence of spatial learning deficit at 6-7 months of age in this AD mouse model. The hearing loss was progressive and extended from high frequency to low frequency. At 3-4 months old, the hearing loss appeared in the whole-frequency range. Moreover, the wave IV and V in the super-threshold ABR were eliminated, indicating substantial impairment in inferior colliculus, nuclei of lateral lemniscus, and medial geniculate body in the upper brainstem. DPOAE in APP/PS1 AD mice was also reduced. However, there was no reduction in CM in APP/PS1 mice. These data demonstrate that unlike age-related hearing loss APP/PS1 AD mice have early onset of hearing loss. These data also suggest that hearing function testing could provide a simple, sensitive, non-invasive screen-tool for early detecting AD and localizing lesion.

Alzheimer's disease Hearing loss Auditory brainstem response Auditory brainstem Early AD biomarker Preclinical AD Age-related hearing loss

SCI

英语

其他

NIH[R01 DC 017025] ; NIH[DC 017025-0151] ; NIH[R56 DC 016585]

Neurosciences & Neurology

Neurosciences

WOS:000509631700011

ELSEVIER IRELAND LTD

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Univ Kentucky, Dept Otolaryngol, Med Ctr, 800 Rose St, Lexington, KY 40536 USA
2.Nankai Univ, Affiliated Hosp, Tianjin Union Med Ctr, Dept Otolaryngol, 190 Jieyuan Rd, Tianjin 300121, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Guangzhou 510080, Peoples R China

Liu, Yang,Fang, Shu,Liu, Li-Man,et al. Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice[J]. NEUROSCIENCE LETTERS,2020,717.

Liu, Yang.,Fang, Shu.,Liu, Li-Man.,Zhu, Yan.,Li, Chang-Ri.,...&Zhao, Hong-Bo.(2020).Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice.NEUROSCIENCE LETTERS,717.

Liu, Yang,et al."Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice".NEUROSCIENCE LETTERS 717(2020).