An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing

Sun, Feifei1; Bu, Yazhong1; Chen, Yourong3; Yang, Fei1; Yu, Jiakuo3; Wu, Decheng1,2

2020

10.1021/acsami.0c01022

ACS Applied Materials and Interfaces   影响因子和分区

19448252

1944-8252

Designing versatile functional medical adhesives with injectability, self-healing, and strong adhesion is of great significance to achieve desirable therapeutic effects for promoting wound sealing in healthcare. Herein, a self-healing injectable adhesive is fabricated by physical interaction of polyphenol compound tannic acid (TA) and eight-arm poly(ethylene glycol) end-capped with succinimide glutarate active ester (PEG-SG). The hydrogen bonding induced from the structural unit (-CH2-CH2-O-) of PEG and catechol hydroxyl (-OH) of TA, accompanied by ester exchange between N-hydroxysuccinimide (-NHS) and amino (-NH2) of proteins, contributes to self-healing ability and rapid strong adhesion. Notably, the PEG/TA adhesive can repeatedly adhere to rigid porcine tissues, close the coronary artery under a large incision tension, and bear a heavy load of 2 kg. By exhibiting shear-thinning and anti-swelling properties, the PEG/TA adhesive can be easily applied through single-syringe extrusion onto various wounds. The single-channel toothpaste-like feature of the adhesive ensures its storage hermetically for portable usage. Moreover, in vivo operation and histological H&E staining results indicate that the PEG/TA adhesive greatly accelerates wound healing and tissue regeneration in a rat model. With the specialty of injectability, instant self-healing, and long-lasting strong adhesion to facilitate excellent therapeutic effects, the multifunctional PEG/TA adhesive may provide a new alternative for self-rescue and surgical situations.
Copyright © 2020 American Chemical Society.

adhesive single channel/injectable poly(ethylene glycol) self-healing wound sealing

SCI ; EI

英语

其他

China Postdoctoral Science Foundation[2018 M641483] ; National Natural Science Foundation of China[81630056]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000517360000017

American Chemical Society

20201108276186

Adhesion ; Esters ; Ethylene glycol ; Hydrogen bonds ; Polyethylene glycols ; Polyols ; Self-healing materials ; Shear thinning ; Tensile strength ; Tissue ; Tissue regeneration

Metals, Plastics, Wood and Other Structural Materials:415 ; Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Fluid Flow, General:631.1 ; Physical Chemistry:801.4 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Materials Science:951

Web of Science

1.Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing; 100190, China
2.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen; Guangdong; 518055, China
3.Knee Surgery Department of the Institute of Sports Medicine, Peking University Third Hospital, Beijing; 100191, China

Sun, Feifei,Bu, Yazhong,Chen, Yourong,et al. An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing[J]. ACS Applied Materials and Interfaces,2020,12(8):9132-9140.

Sun, Feifei,Bu, Yazhong,Chen, Yourong,Yang, Fei,Yu, Jiakuo,&Wu, Decheng.(2020).An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing.ACS Applied Materials and Interfaces,12(8),9132-9140.

Sun, Feifei,et al."An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing".ACS Applied Materials and Interfaces 12.8(2020):9132-9140.