南方科技大学知识苑(SUSTech KC): Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

题名	Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin
作者	Low, Zhen Jie 1; Xiong, Juan 1,2; Xie, Ying 1; Ma, Guang-Lei 1; Saw, Howard 1; Tran, Hoa Thi 1; Wong, Soo Lin 1; Pang, Li Mei 1; Fong, July 3; Lu, Peng 1; Hu, Jin-Feng 2; Yang, Liang4 ; Miao, Yansong 1; Liang, Zhao-Xun 1,3
通讯作者	Miao, Yansong; Liang, Zhao-Xun
发表日期	2020-01-16
DOI	10.1039/c9cc08908j
发表期刊	CHEMICAL COMMUNICATIONS 影响因子和分区
ISSN	1359-7345
EISSN	1364-548X
卷号	56 期号:5页码:822-825
摘要	Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
重要成果	NI论文
学校署名	其他
资助项目	NSFC[21937002]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000507866200030
出版者	ROYAL SOC CHEMISTRY
EI入藏号	20201608462196
EI主题词	Alcohols ; Biochemistry ; Cell membranes
EI分类号	Biological Materials and Tissue Engineering:461.2 ; Biotechnology:461.8 ; Biochemistry:801.2 ; Chemical Reactions:802.2 ; Organic Compounds:804.1
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：16
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/104681
专题	南方科技大学医学院
作者单位	1.Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore 2.Fudan Univ, Sch Pharm, Shanghai, Peoples R China 3.Nanyang Technol Univ, SCELSE, Singapore 637551, Singapore 4.Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Low, Zhen Jie,Xiong, Juan,Xie, Ying,et al. Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin[J]. CHEMICAL COMMUNICATIONS,2020,56(5):822-825.
APA	Low, Zhen Jie.,Xiong, Juan.,Xie, Ying.,Ma, Guang-Lei.,Saw, Howard.,...&Liang, Zhao-Xun.(2020).Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin.CHEMICAL COMMUNICATIONS,56(5),822-825.
MLA	Low, Zhen Jie,et al."Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin".CHEMICAL COMMUNICATIONS 56.5(2020):822-825.