| 题名 | Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin |
| 作者 | |
| 通讯作者 | Miao, Yansong; Liang, Zhao-Xun |
| 发表日期 | 2020-01-16
|
| DOI | |
| 发表期刊 | |
| ISSN | 1359-7345
|
| EISSN | 1364-548X
|
| 卷号 | 56期号:5页码:822-825 |
| 摘要 | Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 其他
|
| 资助项目 | NSFC[21937002]
|
| WOS研究方向 | Chemistry
|
| WOS类目 | Chemistry, Multidisciplinary
|
| WOS记录号 | WOS:000507866200030
|
| 出版者 | |
| EI入藏号 | 20201608462196
|
| EI主题词 | Alcohols
; Biochemistry
; Cell membranes
|
| EI分类号 | Biological Materials and Tissue Engineering:461.2
; Biotechnology:461.8
; Biochemistry:801.2
; Chemical Reactions:802.2
; Organic Compounds:804.1
|
| ESI学科分类 | CHEMISTRY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：16
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/104681 |
| 专题 | 南方科技大学医学院 |
| 作者单位 | 1.Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore 2.Fudan Univ, Sch Pharm, Shanghai, Peoples R China 3.Nanyang Technol Univ, SCELSE, Singapore 637551, Singapore 4.Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Low, Zhen Jie,Xiong, Juan,Xie, Ying,et al. Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin[J]. CHEMICAL COMMUNICATIONS,2020,56(5):822-825.
|
| APA |
Low, Zhen Jie.,Xiong, Juan.,Xie, Ying.,Ma, Guang-Lei.,Saw, Howard.,...&Liang, Zhao-Xun.(2020).Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin.CHEMICAL COMMUNICATIONS,56(5),822-825.
|
| MLA |
Low, Zhen Jie,et al."Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin".CHEMICAL COMMUNICATIONS 56.5(2020):822-825.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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