| 题名 | Analysis of autophagy-related genes and associated noncoding RNAs and transcription factors in digestive system tumors |
| 作者 | |
| 通讯作者 | Dai, Yong; Chen, Wenbiao |
| 发表日期 | 2019-12
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| DOI | |
| 发表期刊 | |
| ISSN | 1479-6694
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| EISSN | 1744-8301
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| 卷号 | 15期号:36页码:4141-4154 |
| 摘要 | Aim: To investigate the autophagy-related gene (ATG) expression and the associated noncoding RNAs (ncRNA) and transcription factors (TF) in digestive system tumors (DST). Methods: We systematically investigated the ATG expression in DST by weighted gene correlation network analysis, crosstalk connection, functional analysis and Pivot analysis. Results: ATGs were clustered into six modules with co-expression in DST. Functional analysis revealed that six ATG-related modules were enriched in biological pathways involved in tumorigenesis. Pivot analysis identified key ncRNAs and TFs, which are essential for the pathogenesis, clinical diagnosis and treatment of DST. Conclusion: Our study highlights the crucial roles of ncRNA and TFs in the identification of potential biomarkers or therapeutic targets for DST. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
; 通讯
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| 资助项目 | Key Research and Development Program of Guangdong Province[2019B020229001]
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| WOS研究方向 | Oncology
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| WOS类目 | Oncology
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| WOS记录号 | WOS:000508023400004
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：3
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/104721 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Zhejiang Univ, Affiliated Hosp 1, Collaborat Innovat Ctr Diag & Treatment Infect Di, Coll Med,Natl Clin Res Ctr Infect Dis,State Key L, Hangzhou, Zhejiang, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Dept Clin Med R, Shenzhen 518020, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Clin Med Coll 2,Shenzhen Peoples Hosp,Dept Gastro, Shenzhen 518020, Guangdong, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Lin, Liewen,Xia, Ligang,Tang, Donge,et al. Analysis of autophagy-related genes and associated noncoding RNAs and transcription factors in digestive system tumors[J]. Future Oncology,2019,15(36):4141-4154.
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| APA |
Lin, Liewen,Xia, Ligang,Tang, Donge,Dai, Yong,&Chen, Wenbiao.(2019).Analysis of autophagy-related genes and associated noncoding RNAs and transcription factors in digestive system tumors.Future Oncology,15(36),4141-4154.
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| MLA |
Lin, Liewen,et al."Analysis of autophagy-related genes and associated noncoding RNAs and transcription factors in digestive system tumors".Future Oncology 15.36(2019):4141-4154.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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