| 题名 | Promoter hypermethylation of the CFTR gene as a novel diagnostic and prognostic marker of breast cancer |
| 作者 | |
| 通讯作者 | Wang, Jianhong; Zhou, Wenbin; Zou, Chang |
| 发表日期 | 2020-02
|
| DOI | |
| 发表期刊 | |
| ISSN | 1065-6995
|
| EISSN | 1095-8355
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| 卷号 | 44期号:2页码:603-609 |
| 摘要 | Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer-related deaths among women. New biomarkers with definite diagnostic and prognostic efficacy are urgently needed. Here, we showed that the promoter of the cystic fibrosis transmembrane conductance regulator (CFTR) was hypermethylated in breast cancer. The messenger RNA level of CFTR was downregulated in breast cancer. Notably, all 19 breast cancer patients with hypermethylated CFTR were diagnosed with invasive carcinoma. Moreover, CFTR was upregulated in decitabine (10 mu M) treated breast cancer cells. Overexpression of CFTR inhibited cell growth whereas knockdown of CFTR promoted cell invasion. In the tissue array analysis, the CFTR protein level decreased significantly in breast cancer and low CFTR protein level correlated with poor survival with a P-value of 0.034. Thus, promoter hypermethylation of the CFTR gene might be a novel diagnostic marker of breast cancer. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 通讯
|
| 资助项目 | Science and Technology Foundation of Shenzhen[JCYJ20180301170047864]
; Science and Technology Foundation of Shenzhen[GJHZ20180928171802117]
|
| WOS研究方向 | Cell Biology
|
| WOS类目 | Cell Biology
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| WOS记录号 | WOS:000509570400023
|
| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
|
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：17
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/104765 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | Jinan Univ, Southern Univ Sci & Technol, Clin Med Coll 2, Shenzhen Peoples Hosp,Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Liu, Kaisheng,Dong, Fajin,Gao, Hengyuan,et al. Promoter hypermethylation of the CFTR gene as a novel diagnostic and prognostic marker of breast cancer[J]. CELL BIOLOGY INTERNATIONAL,2020,44(2):603-609.
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| APA |
Liu, Kaisheng.,Dong, Fajin.,Gao, Hengyuan.,Guo, Yaomin.,Li, Haili.,...&Zou, Chang.(2020).Promoter hypermethylation of the CFTR gene as a novel diagnostic and prognostic marker of breast cancer.CELL BIOLOGY INTERNATIONAL,44(2),603-609.
|
| MLA |
Liu, Kaisheng,et al."Promoter hypermethylation of the CFTR gene as a novel diagnostic and prognostic marker of breast cancer".CELL BIOLOGY INTERNATIONAL 44.2(2020):603-609.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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