南方科技大学知识苑(SUSTech KC): CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD

题名	CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD
作者	Peng, Junming; Jiang, Hongtao; Guo, Jinan; Huang, Jiansheng; Yuan, Qian; Xie, Jing; Xiao, Kefeng
通讯作者	Xiao, Kefeng
发表日期	2020-02-21
DOI	10.1155/2020/7638975
发表期刊	Biomed Research International 影响因子和分区
ISSN	2314-6133
EISSN	2314-6141
卷号	2020
摘要	Purpose. CD147, also known as BSG, is a type I transmembrane glycoprotein that belonged to immunoglobulin superfamily. Mature CD147 is an N-linked glycosylated protein and exists on the transmembrane and as soluble forms in tumors. However, the function of CD147 in cell proliferation of bladder cancer (BC) remains to be elucidated. Methods. The study included 159 patients with BC and 68 healthy controls. The expression of CD147 and gasdermin D (GSDMD) was analyzed by immunohistochemistry (IHC). Western blotting was performed to detect the expression of proteins in BC cells. The relationship between CD147 and GSDMD was analyzed by the IHC score. Results. The expression of CD147 was significantly increased in BC when compared to healthy controls, and the level of CD147 was correlated with tumor proliferation characterized by Ki-67, which is a cell proliferation antigen. In addition, CD147 treatment of BC cells increased the expression of GSDMD, leading to increased Ki-67 expression, while CD147 blockade with peptide in BC significantly reduced GSDMD expression, resulting in reduced cell proliferation. Furthermore, overexpression of GSDMD markedly overcame the inhibitory effect of CD147 peptide on tumor proliferation. BC patients with overexpression of CD147 showed correlation with GSDMD and demonstrated significantly poorer prognosis and overall survival rate. Conclusion. These findings suggested that high expression of CD147 contributed to tumor proliferation in BC via GSDMD, which might in turn act as an unfavorable prognostic marker.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Natural Science Foundation of Fujian Province[2016J05176]
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS记录号	WOS:000518930600005
出版者	HINDAWI LTD
来源库	Web of Science
引用统计	被引频次[WOS]：27
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/104807
专题	南方科技大学第一附属医院
作者单位	Southern Univ Sci & Technol, Dept Urol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen 518000, Guangdong, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Peng, Junming,Jiang, Hongtao,Guo, Jinan,et al. CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD[J]. Biomed Research International,2020,2020.
APA	Peng, Junming.,Jiang, Hongtao.,Guo, Jinan.,Huang, Jiansheng.,Yuan, Qian.,...&Xiao, Kefeng.(2020).CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD.Biomed Research International,2020.
MLA	Peng, Junming,et al."CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD".Biomed Research International 2020(2020).