Evaluation of visible NIR-I and NIR-II light penetration for photoacoustic imaging in rat organs

Sun，Aihui1,2; Guo，Heng1,3; Gan，Qi4; Yang，Lei5; Liu，Qiang1; Xi，Lei1

2020-03-16

10.1364/OE.389714

OPTICS EXPRESS   影响因子和分区

1094-4087

1094-4087

In this study, we evaluate the penetration capability of light in visible, near-infrared-I (NIR-I) and near-infrared-II (NIR-II) optical windows for photoacoustic macroscale imaging inside 9 biological tissues with three typical penetration depths. An acoustic resolution photoacoustic microscopy is designed to guarantee the consistent experiment conditions except excitation wavelength. Experimental results show that short NIR-II (1000-1150 nm) shows the best performance inside kidney, spleen and liver tissues at all depths, while NIR-I (700-1000 nm) works better for muscle, stomach, heart and brain tissues, especially in deep imaging. This study proposes the optimal selection of illumination wavelengths for photoacoustic macroscale imaging in rat organs, which enables the best signal-to-noise ratio (SNR) of the observed target.

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[61775028]

Optics

Optics

WOS:000522511600102

OPTICAL SOC AMER

20201208332390

Photoacoustic effect ; Photoacoustic microscopy ; Signal to noise ratio ; Infrared devices ; Tissue ; Histology

Biological Materials and Tissue Engineering:461.2 ; Information Theory and Signal Processing:716.1 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Acoustic Waves:751.1

PHYSICS

2-s2.0-85081957256

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China
2.School of Life Science and Technology,Harbin Institute of Technology,Harbin, Heilongjiang,15001,China
3.School of Physics,University of Electronic Science and Technology of China,Chengdu, Sichuan,610054,China
4.Department of Neurosurgery,West China Hospital Sichuan University,Chengdu, Sichuan,610041,China
5.Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu, Sichuan,610041,China

Sun，Aihui,Guo，Heng,Gan，Qi,et al. Evaluation of visible NIR-I and NIR-II light penetration for photoacoustic imaging in rat organs[J]. OPTICS EXPRESS,2020,28(6):9002-9013.

Sun，Aihui,Guo，Heng,Gan，Qi,Yang，Lei,Liu，Qiang,&Xi，Lei.(2020).Evaluation of visible NIR-I and NIR-II light penetration for photoacoustic imaging in rat organs.OPTICS EXPRESS,28(6),9002-9013.

Sun，Aihui,et al."Evaluation of visible NIR-I and NIR-II light penetration for photoacoustic imaging in rat organs".OPTICS EXPRESS 28.6(2020):9002-9013.