Recent Advances in the Construction of Trifluoromethyl-Containing Spirooxindoles through Cycloaddition Reactions

Gui，Hou Ze1; Wei，Yin2; Shi，Min1,2,3

2020

10.1002/asia.202000054

Chemistry-An Asian Journal   影响因子和分区

1861-4728

1861-471X

The spirooxindole unit is one of the most widely investigated compound skeletons existing in numerous natural and pharmaceutical molecules. Thus, a large number of synthetic methodologies have already been reported to construct such a core structure. The trifluoromethyl group is another privileged unit in organic chemistry. The introduction of a CF group to an organic framework can significantly improve the properties of the molecule. In this context, an efficient approach for the construction of trifluoromethyl-containing spirooxindoles becomes a promising research direction among communities of industry and academia. In this Minireview, recent advances in the construction of trifluoromethyl-containing spirooxindoles have been summarized and discussed. In addition, representative synthetic methodologies and the corresponding reaction mechanisms have been described as well.

cycloaddition reaction isatin-derived α-(trifluoromethyl)imine spirooxindole trifluoromethyl group

SCI ; EI

英语

其他

WOS:000520530500001

20201308342910

Cycloaddition

Chemical Reactions:802.2 ; Atomic and Molecular Physics:931.3

2-s2.0-85082069763

Scopus

1.Key Laboratory for Advanced Materials and Institute of Fine Chemicals,School of Chemistry & Molecular Engineering,East China University of Science and Technology,Shanghai,Meilong Road No.130,200237,China
2.State Key Laboratory of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,University of Chinese Academy of Sciences,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,345 Lingling Road,200032,China
3.Shenzhen Grubbs Institute,Southern University of Science and Technology,Shenzhen,518000,China

Gui，Hou Ze,Wei，Yin,Shi，Min. Recent Advances in the Construction of Trifluoromethyl-Containing Spirooxindoles through Cycloaddition Reactions[J]. Chemistry-An Asian Journal,2020,15:1225-1233.

Gui，Hou Ze,Wei，Yin,&Shi，Min.(2020).Recent Advances in the Construction of Trifluoromethyl-Containing Spirooxindoles through Cycloaddition Reactions.Chemistry-An Asian Journal,15,1225-1233.

Gui，Hou Ze,et al."Recent Advances in the Construction of Trifluoromethyl-Containing Spirooxindoles through Cycloaddition Reactions".Chemistry-An Asian Journal 15(2020):1225-1233.