Anti-tuberculosis (TB) chemotherapy dynamically rescues Th1 and CD8+ T effector levels in Han Chinese pulmonary TB patients

Li，Guobao1; Yang，Fang2; He，Xing3; Liu，Zhi1; Pi，Jiang2,7; Zhu，Yuzhen4; Ke，Xue1; Liu，Shuyan1; Ou，Min1; Guo，Huixin5; Zhang，Zhuoran6; Zeng，Gucheng2; Zhang，Guoliang3

2019

10.1016/j.micinf.2019.10.001

MICROBES AND INFECTION   影响因子和分区

1286-4579

1769-714X

CD4+/CD8+ T cells play a major role in conferring immune protection against tuberculosis (TB), but it remains unknown how the immune responses of CD4+/CD8+ T cells exactly correlate with the clinical variables and disease statuses during anti-TB chemotherapy. To address this, several major immune parameters of CD4+/CD8+ T cells in peripheral blood derived from pulmonary TB patients and healthy volunteers were evaluated. We observed that active TB infection induced lower CD3+ T cell and CD4+ T cell levels but higher CD8+T cell levels, while anti-TB chemotherapy reversed these effects. Also, anti-TB treatment induced enhanced production of IL-2 and IFN-γ but reduced expression of IL-10 and IL-6. Moreover, the dynamic changes of CD3, CD4, and CD8 levels did not show a significant association with sputum smear positivity. However, the frequencies of IL-2+CD4+ or IL-10 + CD4+ T effector subpopulation or IL-1β production in peripheral blood showed significant difference between patients positive for sputum smear and patients negative for sputum smear after anti-TB treatment. These findings implicated that recovery of Th1/CD8+T cell effector levels might be critical immunological events in pulmonary TB patients after treatment and further suggested the importance of these immunological parameters as potential biomarkers for prediction of TB progress and prognosis.

Anti-TB treatment Immunological recovery Tuberculosis

SCI

英语

第一

National Key RD Plan Grant[2016YFE0106900] ; NSFC[81622029][31670879][81361120379][81873958][81801649] ; National Science and Technology Major Project[2017ZX10201301][SQ2017ZX106019] ; 111 Project[B12003] ; Guangdong Natural Science Foundation[2015A030306028][2018A030313118] ; Guangdong Science and Technology Project[2018A050506032] ; National Science and Technology Major Project for Control and Prevention of Major Infectious Diseases of China[2017ZX10103004] ; Shenzhen Scientific and Technological Foundation[JCYJ20170412151620658][JCYJ20170307095003051] ; Guangzhou Science and Technology Project[201904010273][201904010455] ; China Postdoctoral Science Foundation[2018M631026] ; Fundamental Research Funds for the Central Universities[19ykpy161] ; Shanghai Key Laboratory of Tuberculosis (lung) Grant[2018kf04]

Immunology ; Infectious Diseases ; Microbiology

Immunology ; Infectious Diseases ; Microbiology

WOS:000529329300005

ELSEVIER

IMMUNOLOGY

2-s2.0-85075517866

Scopus

1.Department of Tuberculosis,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,518112,China
2.Department of Microbiology,Zhongshan School of Medicine,Key Laboratory for Tropical Diseases Control of the Ministry of Education,Sun Yat-sen University,Guangzhou,510080,China
3.National Clinical Research Center for Tuberculosis,Guangdong Key Laboratory for Emerging Infectious Diseases,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,518112,China
4.Guangdong Key Laboratory for Research and Development of Natural Drugs,Guangdong Medical University,Zhanjiang,524023,China
5.National Clinical Research Center for Tuberculosis and Guangdong Center for Tuberculosis Control,Guangzhou,510430,China
6.Beckman Research Institute,City of Hope National Cancer Center,Duarte,92618,United States
7.Department of Microbiology and Immunology,University of Illinois at Chicago,Chicago,60612,United States

Li，Guobao,Yang，Fang,He，Xing,et al. Anti-tuberculosis (TB) chemotherapy dynamically rescues Th1 and CD8+ T effector levels in Han Chinese pulmonary TB patients[J]. MICROBES AND INFECTION,2019,22(3):119-126.

Li，Guobao.,Yang，Fang.,He，Xing.,Liu，Zhi.,Pi，Jiang.,...&Zhang，Guoliang.(2019).Anti-tuberculosis (TB) chemotherapy dynamically rescues Th1 and CD8+ T effector levels in Han Chinese pulmonary TB patients.MICROBES AND INFECTION,22(3),119-126.

Li，Guobao,et al."Anti-tuberculosis (TB) chemotherapy dynamically rescues Th1 and CD8+ T effector levels in Han Chinese pulmonary TB patients".MICROBES AND INFECTION 22.3(2019):119-126.