Assessing the role of live poultry trade in community-structured transmission of avian influenza in China

Yang, Qiqi1; Zhao, Xiang2; Lemey, Philippe3; Suchard, Marc A.4,5,6; Bi, Yuhai7,8; Shi, Weifeng9; Liu, Di10; Qi, Wenbao11; Zhang, Guogang12; Stenseth, Nils Chr.13; Pybus, Oliver G.14,15; Tian, Huaiyu1

2020-03-17

10.1073/pnas.1906954117

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   影响因子和分区

0027-8424

The live poultry trade is thought to play an important role in the spread and maintenance of highly pathogenic avian influenza A viruses (HP AIVs) in Asia. Despite an abundance of small-scale observational studies, the role of the poultry trade in disseminating AIV over large geographic areas is still unclear, especially for developing countries with complex poultry production systems. Here we combine virus genomes and reconstructed poultry transportation data to measure and compare the spatial spread in China of three key subtypes of AIV: H5N1, H7N9, and H5N6. Although it is difficult to disentangle the contribution of confounding factors, such as bird migration and spatial distance, we find evidence that the dissemination of these subtypes among domestic poultry is geographically continuous and likely associated with the intensity of the live poultry trade in China. Using two independent data sources and network analysis methods, we report a regional-scale community structure in China that might explain the spread of AIV subtypes in the country. The identification of this structure has the potential to inform more targeted strategies for the prevention and control of AIV in China.

avian influenza poultry trade phylogeography community-structured transmission

SCI

英语

NI期刊

其他

Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen)[G066215N] ; Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen)[G0D5117N] ; Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen)[G0B9317N]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000520011000055

NATL ACAD SCIENCES

BIOLOGY & BIOCHEMISTRY;CLINICAL MEDICINE;MULTIDISCIPLINARY;PLANT & ANIMAL SCIENCE;ENVIRONMENT/ECOLOGY;SOCIAL SCIENCES, GENERAL;MICROBIOLOGY;ECONOMICS BUSINESS;IMMUNOLOGY;MATERIALS SCIENCE;MATHEMATICS;SPACE SCIENCE;MOLECULAR BIOLOGY & GENETICS;PHARMACOLOGY & TOXICOLOGY;CHEMISTRY;PSYCHIATRY/PSYCHOLOGY;NEUROSCIENCE & BEHAVIOR;PHYSICS;GEOSCIENCES;AGRICULTURAL SCIENCES;ENGINEERING

Web of Science

1.Beijing Normal Univ, Coll Global Change & Earth Syst Sci, State Key Lab Remote Sensing Sci, Beijing 100875, Peoples R China
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3.Katholieke Univ Leuven, Rega Inst Clin & Epidemiol Virol, Dept Microbiol Immunol & Transplantat, B-3000 Leuven, Belgium
4.Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USA
5.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
6.Univ Calif Los Angeles, UCLA Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA
7.Southern Univ Sci & Technol, Guangdong Key Lab Diag & Treatment Emerging Infec, Shenzhen Peoples Hosp 3,State Key Discipline, Shenzhen Key Lab Pathogen & Immun,Hosp 2, Shenzhen 518112, Peoples R China
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9.Taishan Med Coll, Inst Pathogen Biol, Tai An 271000, Shandong, Peoples R China
10.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China
11.South China Agr Univ, Coll Vet Med, Natl & Reg Joint Engn Lab Medicament Zoonoses Pre, Guangzhou 510642, Peoples R China
12.Chinese Acad Forestry, Key Lab Forest Protect State Forestry & Grassland, Res Inst Forest Ecol Environm & Protect, Natl Bird Banding Ctr China, Beijing 100091, Peoples R China
13.Univ Oslo, Dept Biosci, CEES, N-0316 Oslo, Norway
14.Univ Oxford, Dept Zool, Oxford OX1 3PS, England
15.Royal Vet Coll, Dept Pathobiol & Populat Sci, London AL9 7TA, England

Yang, Qiqi,Zhao, Xiang,Lemey, Philippe,et al. Assessing the role of live poultry trade in community-structured transmission of avian influenza in China[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2020,117(11):5949-5954.

Yang, Qiqi.,Zhao, Xiang.,Lemey, Philippe.,Suchard, Marc A..,Bi, Yuhai.,...&Tian, Huaiyu.(2020).Assessing the role of live poultry trade in community-structured transmission of avian influenza in China.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,117(11),5949-5954.

Yang, Qiqi,et al."Assessing the role of live poultry trade in community-structured transmission of avian influenza in China".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117.11(2020):5949-5954.