Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

Liu, Yan1,2; Wang, Shan3,4; Kan, Jun5; Zhang, Jingzhi6; Zhou, Lisa7; Huang, Yuli8; Zhang, Yunlong1,9

2020

10.2174/1570159X17666191101125530

Current Neuropharmacology   影响因子和分区

1570-159X

1875-6190

Glutamate is the major excitatory neurotransmitter in the central nervous system, and its signaling is critical for excitatory synaptic transmission. The well-established glutamate system involves glutamate synthesis, presynaptic glutamate release, glutamate actions on the ionotropic glutamate receptors (NMDA, AMPA, and kainate receptors) and metabotropic glutamate receptors, and glutamate uptake by glutamate transporters. When the glutamate system becomes dysfunctional, it contributes to the pathogenesis of neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease, Parkinson's disease, depression, epilepsy, and ischemic stroke. In this review, based on regulating glutamate signaling, we summarize the effects and underlying mechanisms of natural constituents from Chinese herbal medicines on neurological disorders. Natural constituents from Chinese herbal medicine can prevent the glutamate-mediated excitotoxicity via suppressing presynaptic glutamate release, decreasing ionotropic and metabotropic glutamate receptors expression in the excitatory synapse, and promoting astroglial glutamate transporter expression to increase glutamate clearance from the synaptic cleft. However, some natural constituents from Chinese herbal medicine have the ability to restore the collapse of excitatory synapses by promoting presynaptic glutamate release and increasing ionotropic and metabotropic glutamate receptors expression. These regulatory processes involve various signaling pathways, which lead to different mechanistic routes of protection against neurological disorders. Hence, our review addresses the underlying mechanisms of natural constituents from Chinese herbal medicines that regulate glutamate systems and serve as promising agents for the treatment of the above-mentioned neurological disorders.

Neurological disorders natural constituents chinese herbal medicine glutamate glutamate receptors glutamate transporters

SCI

英语

其他

Startup Research Fund of Guangzhou Medical University[B195002002045]

Neurosciences & Neurology ; Pharmacology & Pharmacy

Neurosciences ; Pharmacology & Pharmacy

WOS:000521731700001

BENTHAM SCIENCE PUBL LTD

Web of Science

1.Guangzhou Med Univ, Sch Basic Med Sci, Key Lab Neurosci, Guangzhou 511436, Peoples R China
2.Xiamen Univ, Sch Med, Dept Tradit Chinese Med, Xiamen 361102, Peoples R China
3.Southern Univ Sci & Technol, Dept Biol, Ctr Pain Med, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Med Sch, Shenzhen 518055, Peoples R China
5.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Guangzhou 510006, Peoples R China
6.Guangzhou Med Univ, Affiliated Hosp 2, Dept Tradit Chinese Med, Guangzhou 510260, Peoples R China
7.Sanford Burnham Prebys Med Discovery Inst, Neurosci Initiat, La Jolla, CA 92037 USA
8.Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde Foshan 1, Dept Cardiol, Foshan 528300, Peoples R China
9.Xiamen Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China

Liu, Yan,Wang, Shan,Kan, Jun,et al. Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling[J]. Current Neuropharmacology,2020,18(4):260-276.

Liu, Yan.,Wang, Shan.,Kan, Jun.,Zhang, Jingzhi.,Zhou, Lisa.,...&Zhang, Yunlong.(2020).Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling.Current Neuropharmacology,18(4),260-276.

Liu, Yan,et al."Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling".Current Neuropharmacology 18.4(2020):260-276.