南方科技大学知识苑(SUSTech KC): The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization

题名	The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization
作者	Tang, Dong-E.1; Dai, Yong 1; Xu, Yong1 ; Lin, Lie-Wen 1; Liu, Dong-Zhou 1; Hong, Xiao-Ping ; Ou, Ming-Lin 1; Jiang, Hao-Wu 2,3; Xu, Song-Hui 1,4,5
通讯作者	Xu, Song-Hui
发表日期	2020-01
DOI	10.1093/carcin/bgz085
发表期刊	CARCINOGENESIS 影响因子和分区
ISSN	0143-3334
EISSN	1460-2180
卷号	41 期号:1页码:56-66
摘要	The forkhead box A1 (FOXA1), one of the forkhead class of DNA-binding proteins, functions as a transcription factor and plays a vital role in cellular control of embryonic development and cancer progression. Downregulation of FOXA1 has reported in several types of cancer, which contributes to cancer cell survival and chemoresistance. However, the mechanism for FOXA1 downregulation in cancer remains unclear. Here, we report that the ubiquitination enzyme zinc finger protein 91 (ZFP91) ubiquitinates and destabilizes FOXA1, which promotes cancer cell growth. High level of ZFP91 expression correlates with low level of FOXA1 protein in human gastric cancer (GC) cell lines and patient samples.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Science a Technology Plan of Shenzhen[JCYJ20170307095606266]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000522637700008
出版者	OXFORD UNIV PRESS
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：14
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/125498
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Clin Med Coll 2,Dept Clin Med Res Ctr, Shenzhen 518020, Guangdong, Peoples R China 2.Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA 3.Washington Univ, Sch Med, Ctr Study Itch, St Louis, MO 63110 USA 4.Univ Maryland, Sch Med, Dept Biochem, Baltimore, MD 21201 USA 5.Univ Maryland, Sch Med, Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Tang, Dong-E.,Dai, Yong,Xu, Yong,et al. The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization[J]. CARCINOGENESIS,2020,41(1):56-66.
APA	Tang, Dong-E..,Dai, Yong.,Xu, Yong.,Lin, Lie-Wen.,Liu, Dong-Zhou.,...&Xu, Song-Hui.(2020).The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.CARCINOGENESIS,41(1),56-66.
MLA	Tang, Dong-E.,et al."The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization".CARCINOGENESIS 41.1(2020):56-66.