南方科技大学知识苑(SUSTech KC): Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens

题名	Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens
作者	Wu, Chenxuan 1,2; Xia, Ling 1,2; Huang, Wei 1,2; Xu, Yangfan 1,2; Gu, Yuanxin 1,2; Liu, Chang 1,2; Ji, Luting 1,2; Li, Wenyao 1,2; Wu, Yandong 1,2; Zhou, Kai 3,4; Feng, Xinxin 1,2
通讯作者	Feng, Xinxin
发表日期	2020-04-02
DOI	10.1007/s10096-020-03881-0
发表期刊	EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 影响因子和分区
ISSN	0934-9723
EISSN	1435-4373
卷号	39 期号:9页码:1771-1779
摘要	Pentamidine sensitizes FDA-approved antibiotics to combat Gram-negative pathogens. We screened 1374 FDA-approved non-antibiotics for their ability to be sensitized by pentamidine against Escherichia coli. We identified mitomycin C and mefloquine as potent hits effective against multiple drug-resistant, Gram-negative bacteria. Killing kinetics and an in vivo model with Caenorhabditis elegans (C. elegans) revealed that such combinations produced synergy against colistin-resistant Enterobacter cloacae (E. cloacae). These findings suggest combinations of FDA-approved non-antibiotics, and pentamidine can be repurposed into new antimicrobial agents.
关键词	Pentamidine Sensitizer Non-antibiotics Drug repurposing Gram-negative pathogens
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	State Key Laboratory of Biocatalysis and Enzyme Engineering[SKLBEE2019003]
WOS研究方向	Infectious Diseases ; Microbiology
WOS类目	Infectious Diseases ; Microbiology
WOS记录号	WOS:000523055900001
出版者	SPRINGER
ESI学科分类	MICROBIOLOGY
来源库	Web of Science
引用统计	被引频次[WOS]：11
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/125509
专题	南方科技大学第一附属医院
作者单位	1.Hunan Univ, Inst Chem Biol & Nanomed, State Key Lab Chem Biosensing & Chemometr, Hunan Prov Key Lab Biomacromol Chem Biol, Changsha 410082, Peoples R China 2.Hunan Univ, Dept Chem, Changsha 410082, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen Inst Resp Dis, Shenzhen, Peoples R China 4.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll Jinan 2, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Wu, Chenxuan,Xia, Ling,Huang, Wei,et al. Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,2020,39(9):1771-1779.
APA	Wu, Chenxuan.,Xia, Ling.,Huang, Wei.,Xu, Yangfan.,Gu, Yuanxin.,...&Feng, Xinxin.(2020).Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens.EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,39(9),1771-1779.
MLA	Wu, Chenxuan,et al."Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 39.9(2020):1771-1779.