Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions

Chen, Shiyou1,2,3; Xing, Chenyang1,4; Huang, Dazhou1; Zhou, Chuanhong1; Ding, Bo5; Guo, Ziheng6; Peng, Zhengchun4; Wang, Dou3; Zhu, Xi7; Liu, Shuzhen8; Cai, Zhen9; Wu, Jieyu2; Zhao, Jiaqi3; Wu, Zongze3; Zhang, Yuhua3; Wei, Chaoying3; Yan, Qiaoting3; Wang, Hongzhong3; Fan, Dianyuan1; Liu, Liping3; Zhang, Han1; Cao, Yihai2

2020-04

10.1126/sciadv.aay6825

Science Advances   影响因子和分区

2375-2548

Two-dimensional nanomaterial-based photothermal therapy (PTT) is currently under intensive investigation as a promising approach toward curative cancer treatment. However, high toxicity, moderate efficacy, and low uniformity in shape remain critical unresolved issues that hamper their clinical application. Thus, there is an urgent need for developing versatile nanomaterials to meet clinical expectations. To achieve this goal, we developed a stable, highly uniform in size, and nontoxic nanomaterials made of tellurium-selenium (TeSe)-based lateral heterojunction. Systemic delivery of TeSe nanoparticles in mice showed highly specific accumulation in tumors relative to other healthy tissues. Upon exposure to light, TeSe nanoparticles nearly completely eradicated lung cancer and hepatocellular carcinoma in preclinical models. Consistent with tumor suppression, PTT altered the tumor microenvironment and induced immense cancer cell apoptosis. Together, our findings demonstrate an exciting and promising PTT-based approach for cancer eradication.

SCI ; EI

英语

NI论文

通讯

European Research Council (ERC) advanced grant ANGIOFAT[250021]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000525751400019

AMER ASSOC ADVANCEMENT SCIENCE

Web of Science

1.Shenzhen Univ, Shenzhen Engn Lab Phosphorene & Optoelect, Int Collaborat Lab 2D Mat Optoelect Sci & Technol, Minist Educ,Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China
2.Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
4.Shenzhen Univ, Coll Phys & Optoelect Engn, Key Lab Optoelect Devices & Syst, Ctr Stretchable Elect & Nanoscale Syst,Minist Edu, Shenzhen 518060, Peoples R China
5.Fourth Hosp Jinan, Dept Resp Dis, Jinan 250031, Shandong, Peoples R China
6.Sichuan Univ, West China Sch Med, Dept Pancreat Surg, Chengdu, Peoples R China
7.Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen 518172, Peoples R China
8.Weifang Peoples Hosp, Weifang 261041, Peoples R China
9.Chinese Acad Med Sci, Fuwai Hosp, Shenzhen 518000, Peoples R China

Chen, Shiyou,Xing, Chenyang,Huang, Dazhou,et al. Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions[J]. Science Advances,2020,6(15).

Chen, Shiyou.,Xing, Chenyang.,Huang, Dazhou.,Zhou, Chuanhong.,Ding, Bo.,...&Cao, Yihai.(2020).Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions.Science Advances,6(15).

Chen, Shiyou,et al."Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions".Science Advances 6.15(2020).