Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway

Lan, Yulong1,2; Lou, Jiacheng2; Hu, Jiliang1; Yu, Zhikuan1; Lyu, Wen1; Zhang, Bo1,2

2020-02

10.20892/j.issn.2095-3941.2019.0164

Cancer Biology & Medicine   影响因子和分区

2095-3941

Objective: Temozolomide (TMZ) is commonly used for glioblastoma multiforme (GBM) chemotherapy. However, drug resistance limits its therapeutic effect in GBM treatment. RNA-binding proteins (RBPs) have vital roles in posttranscriptional events. While disturbance of RBP-RNA network activity is potentially associated with cancer development, the precise mechanisms are not fully known. The SNRPG gene, encoding small nuclear ribonucleoprotein polypeptide G, was recently found to be related to cancer incidence, but its exact function has yet to be elucidated.

SNRPG glioblastoma cell cycle temozolomide therapy

SCI

英语

第一 ; 通讯

Basic Research Projects in Colleges and Universities of Liaoning Province[LQ2017033]

Oncology ; Research & Experimental Medicine

Oncology ; Medicine, Research & Experimental

WOS:000525342200011

CHINA ANTI-CANCER ASSOC

Web of Science

1.Southern Univ Sci & Technol, Dept Neurosurg, Shenzhen Peoples Hosp, Clin Med Coll 2,Jinan Univ,Affiliated Hosp 1, Shenzhen 518020, Peoples R China
2.Dalian Med Univ, Dept Neurosurg, Affiliated Hosp 2, Dalian 116023, Peoples R China

Lan, Yulong,Lou, Jiacheng,Hu, Jiliang,et al. Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway[J]. Cancer Biology & Medicine,2020,17(1):112-+.

Lan, Yulong,Lou, Jiacheng,Hu, Jiliang,Yu, Zhikuan,Lyu, Wen,&Zhang, Bo.(2020).Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway.Cancer Biology & Medicine,17(1),112-+.

Lan, Yulong,et al."Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway".Cancer Biology & Medicine 17.1(2020):112-+.