南方科技大学知识苑(SUSTech KC): Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe

题名	Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe
作者	Xu, Yue 1; Deng, Zhangshuang 3; Shi, Yue 1; Chen, Xin 2; Xu, Jingyuan 1; Zhong, Suyun 1; Xiao, Youli 2; Wong, Nai-Kei 4; Zhou, Yiqing 1,2
通讯作者	Zhou, Yiqing
发表日期	2020-03-17
DOI	10.1021/acs.analchem.9b05327
发表期刊	ANALYTICAL CHEMISTRY 影响因子和分区
ISSN	0003-2700
EISSN	1520-6882
卷号	92 期号:6页码:4419-4426
摘要	Cancer cells rely on fatty acid synthase (FASN), a key enzyme for de novo biosynthesis of long chain fatty acids, to sustain their proliferative potential and drive invasion. Unfortunately, conventional FASN assays are technically inadequate for discerning otherwise elusive FASN activity in complex biological milieux, which has hindered progress in the functional study of FASN and development of its inhibitors. Here, we describe a chemical probe with unprecedented selectivity and sensitivity for the labeling of active FASN in living cells, thus demonstrating a new analytical modality for visualizing endogenous FASN activity and exploring opportunities for drug discovery.
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
重要成果	NI论文
学校署名	其他
资助项目	Natural Science Foundation of the Higher Education Institutions of Jiangsu Province of China[19KJB150001]
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
WOS记录号	WOS:000526563900034
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/126937
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Changshu Inst Technol, Sch Biotechnol & Food Engn, Changshu 215500, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst Plant Physiol & Ecol, CAS Key Lab Synthet Biol, Shanghai 200032, Peoples R China 3.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China 4.Southern Univ Sci & Technol, Hosp Affiliated 2, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen 518112, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yue,Deng, Zhangshuang,Shi, Yue,et al. Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe[J]. ANALYTICAL CHEMISTRY,2020,92(6):4419-4426.
APA	Xu, Yue.,Deng, Zhangshuang.,Shi, Yue.,Chen, Xin.,Xu, Jingyuan.,...&Zhou, Yiqing.(2020).Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe.ANALYTICAL CHEMISTRY,92(6),4419-4426.
MLA	Xu, Yue,et al."Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe".ANALYTICAL CHEMISTRY 92.6(2020):4419-4426.