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题名

Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation

作者
通讯作者Deng, Fei; Rao, Zihe; Lou, Zhiyong
发表日期
2020-04-27
DOI
发表期刊
ISSN
2058-5276
卷号5期号:6页码:864-+
摘要

The authors present the full-length structure of the polymerase (L protein) from the severe fever with thrombocytopenia syndrome virus (SFTSV)-a segmented, negative-stranded RNA virus. The structure reveals important details with implications for the understanding of viral transcription and replication, and provides information on the organization of the polymerase core domain, entrance and exit tunnels, as well as the cap-binding and endonuclease domains.

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语种
英语
学校署名
其他
资助项目
Nature Science Foundation of Hubei Province[2019CFB790]
WOS研究方向
Microbiology
WOS类目
Microbiology
WOS记录号
WOS:000528980200002
出版者
来源库
Web of Science
引用统计
被引频次[WOS]:31
成果类型期刊论文
条目标识符http://sustech.caswiz.com/handle/2SGJ60CL/127142
专题生命科学学院_生物系
作者单位
1.Tsinghua Univ, Sch Med, MOE Key Lab Prot Sci, Beijing, Peoples R China
2.Tsinghua Univ, Sch Med, Collaborat Innovat Ctr Biotherapy, Beijing, Peoples R China
3.Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China
4.Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin, Peoples R China
5.Nankai Univ, Coll Pharm, Drug Discovery Ctr Infect Dis, Tianjin, Peoples R China
6.Chinese Acad Sci, Ctr Biosafety Mega Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China
7.Chinese Acad Sci, Ctr Biosafety Mega Sci, Wuhan Inst Virol, Natl Virus Resource Ctr, Wuhan, Hubei, Peoples R China
8.Beijing Computat Sci Res Ctr, Complex Syst Div, Beijing, Peoples R China
9.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China
10.Peking Univ, Hosp 302, Beijing, Peoples R China
11.Chinese Acad Sci, Inst Biophys, Natl Lab Macromol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Panpan,Liu, Lu,Liu, Aijun,et al. Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation[J]. Nature Microbiology,2020,5(6):864-+.
APA
Wang, Panpan.,Liu, Lu.,Liu, Aijun.,Yan, Liming.,He, Yong.,...&Lou, Zhiyong.(2020).Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation.Nature Microbiology,5(6),864-+.
MLA
Wang, Panpan,et al."Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation".Nature Microbiology 5.6(2020):864-+.
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