Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

Song, Yongxiang1,2; Yang, Jiafan1,2; Yu, Jianchen3,4; Li, Jie1,2; Yuan, Jie3,4; Wong, Nai-Kei5; Ju, Jianhua1,2

2020-04-24

10.1038/s41429-020-0307-4

JOURNAL OF ANTIBIOTICS   影响因子和分区

0021-8820

1881-1469

Two new chlorinated bis-indole alkaloids, dionemycin (1) and 6-OMe-7 ',7 ''-dichorochromopyrrolic acid (2), along with seven known analogs 3-9, were isolated from the deep-sea derived Streptomyces sp. SCSIO 11791. Their structures were elucidated by extensive HRESIMS, and 1D and 2D NMR data analysis. In vitro antibacterial and cytotoxic assays revealed that, compound 1, shows anti-staphylococcal activity with an MIC range of 1-2 mu g/mL against six clinic strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from human and pig. Additionally, compound 1 displayed cytotoxic activity against human cancer cell lines NCI-H460, MDA-MB-231, HCT-116, HepG2, and noncancerous MCF10A with an IC50 range of 3.1-11.2 mu M. Analysis of the structure-activity relationship reveals that the chlorine atom at C-6 '' could be pivotal for conferring their bioactivities, thus providing hints on chemical modifications on bis-indole alkaloid scaffold in drug design.

SCI ; IC

英语

其他

Special Fund for Strategic Pilot Technology of Chinese Academy of Sciences[XDA13020302-2]

Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy

Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy

WOS:000528441100001

NATURE PUBLISHING GROUP

PHARMACOLOGY & TOXICOLOGY

Web of Science

1.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Peoples R China
2.Univ Chinese Acad Sci, Coll Oceanol, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510080, Peoples R China
4.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Biochem, Guangzhou 510080, Peoples R China
5.Southern Univ Sci & Technol, Hosp 2, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Shenzhen 518020, Peoples R China

Song, Yongxiang,Yang, Jiafan,Yu, Jianchen,et al. Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities[J]. JOURNAL OF ANTIBIOTICS,2020,73(8):542-547.

Song, Yongxiang.,Yang, Jiafan.,Yu, Jianchen.,Li, Jie.,Yuan, Jie.,...&Ju, Jianhua.(2020).Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities.JOURNAL OF ANTIBIOTICS,73(8),542-547.

Song, Yongxiang,et al."Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities".JOURNAL OF ANTIBIOTICS 73.8(2020):542-547.