Supramolecular assemblies mimicking neutrophil extracellular traps for MRSE infection control

Huang，Zhentao1,3,4; Liu，Ye2; Wang，Le1; Ali，Arbab1; Yao，Qingxin1,4; Jiang，Xingyu1,3,4; Gao，Yuan1,4

2020-09-01

10.1016/j.biomaterials.2020.120124

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

Neutrophil extracellular traps (NETs) stick to bacteria and prevent infections in vivo, whose activation is upon inflammatory stimuli along with the sudden increase of reactive oxygen species (ROS). Nevertheless, the risky over activation in NETosis may result in deleterious outcome. A big challenge in using NETs for therapeutics is to synthesize an artificial system that can function as NETs in vivo. Here, we developed an in vivo supramolecular assembly system to imitate the innate immune process of NETs to inhibit methicillin-resistant staphylococcus epidermidis (MRSE) infection. Our synthesized small molecules undergo oxidation to form supramolecular nanofibers at inflammatory loci. The in situ formed nanofibers network efficiently traps MRSE cells and prevent them from aggressive dissemination. The extended interactions between nanofibers and bacteria directly result in the death of MRSE via the transcriptomes alterations. In clinically relevant models (intraperitoneal infection and catheter implantation), our supramolecular nets show significant antibacterial activity, yielding a three times efficacy comparing to vancomycin. The spontaneous consumption of ROS and the formation of antibacterial networks create a steady negative feedback system to combat bacterial infections.

Antimicrobial resistance Infection Neutrophil extracellular traps Reactive oxygen species Supramolecular self-assembly

SCI ; EI

英语

其他

National Key R&D Program of China[2017YFA0205901] ; NSFC[21675036][51873046][21874033][21535001][81730051][21761142006] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039][121D11KYSB20170026][XDA16020902] ; China Postdoctoral Science Foundation[2019T120074][2019M661683] ; Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2018RC310021]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000536893800007

ELSEVIER SCI LTD

20202108691467

Feedback ; Supramolecular chemistry ; Nanofibers ; Self assembly ; Bacteria ; Oxygen ; Synthesis (chemical)

Control Systems:731.1 ; Nanotechnology:761 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 ; Solid State Physics:933 ; Materials Science:951

MATERIALS SCIENCE

2-s2.0-85084935413

Scopus

1.CAS Center for Excellence in Nanoscience,CAS Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing,100190,China
2.Institute of Medical Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Kunming,650000,China
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.University of Chinese Academy of Sciences,Beijing,100049,China

Huang，Zhentao,Liu，Ye,Wang，Le,et al. Supramolecular assemblies mimicking neutrophil extracellular traps for MRSE infection control[J]. BIOMATERIALS,2020,253.

Huang，Zhentao.,Liu，Ye.,Wang，Le.,Ali，Arbab.,Yao，Qingxin.,...&Gao，Yuan.(2020).Supramolecular assemblies mimicking neutrophil extracellular traps for MRSE infection control.BIOMATERIALS,253.

Huang，Zhentao,et al."Supramolecular assemblies mimicking neutrophil extracellular traps for MRSE infection control".BIOMATERIALS 253(2020).