南方科技大学知识苑(SUSTech KC): Histone Demethylase JMJD1A Promotes Tumor Progression via Activating Snail in Prostate Cancer

题名	Histone Demethylase JMJD1A Promotes Tumor Progression via Activating Snail in Prostate Cancer
作者	Tang, Dong-E 1; Dai, Yong 1; Fan, Ling-Ling 2; Geng, Xin-Yan 2; Fu, De-Xue 3; Jiang, Hao-Wu 4,5; Xu, Song-Hui 1,2
通讯作者	Xu, Song-Hui
发表日期	2020-05
DOI	10.1158/1541-7786.MCR-19-0889
发表期刊	MOLECULAR CANCER RESEARCH 影响因子和分区
ISSN	1541-7786
EISSN	1557-3125
卷号	18 期号:5页码:698-708
摘要	The histone demethylase JMJD1A plays a key functional role in spermatogenesis, sex determination, stem cell renewal, and cancer via removing mono- and di-methyl groups from H3K9 to epigenetically control gene expression. However, its role in prostate cancer progression remains unclear. Here, we found JMJD1A was significantly elevated in prostate cancer tissue compared with matched normal tissue. Ectopic JMJD1A expression in prostate cancer cells promoted proliferation, migration, and invasion in vitro, and tumorigenesis in vivo; JMJD1A knockdown exhibited the opposite effects. Mechanically, we revealed that JMJD1A directly interacted with the Snail gene promoter and regulated its transcriptional activity, promoting prostate cancer progression both in vitro and in vivo. Further-more, we found that JMJD1A transcriptionally activated Snail expression via H3K9me1 and H3K9me2 demethylation at its special promoter region. In summary, our studies reveal JMJD1A plays an important role in regulating proliferation and progression of prostate cancer cells though Snail, and thus highlight JMJD1A as potential therapeutic target for advanced prostate cancer.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[31700795] ; Science & Technology Planning Project of Guangdong Province of China[2017B020209001] ; Natural Science Foundation of Guangdong Province of China[2017A030310629] ; Science & Technology Plan of Shenzhen[JCYJ20170307095606266]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000531797700003
出版者	AMER ASSOC CANCER RESEARCH
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
来源库	Web of Science
引用统计	被引频次[WOS]：12
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/138056
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Clin Med Res Ctr, Clin Med Coll 2,Jinan Univ,Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China 2.Univ Maryland, Sch Med, Dept Biochem, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA 3.Univ Maryland, Sch Med, Dept Surg, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA 4.Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA 5.Washington Univ, Sch Med, Ctr Study Itch, St Louis, MO USA
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Tang, Dong-E,Dai, Yong,Fan, Ling-Ling,et al. Histone Demethylase JMJD1A Promotes Tumor Progression via Activating Snail in Prostate Cancer[J]. MOLECULAR CANCER RESEARCH,2020,18(5):698-708.
APA	Tang, Dong-E.,Dai, Yong.,Fan, Ling-Ling.,Geng, Xin-Yan.,Fu, De-Xue.,...&Xu, Song-Hui.(2020).Histone Demethylase JMJD1A Promotes Tumor Progression via Activating Snail in Prostate Cancer.MOLECULAR CANCER RESEARCH,18(5),698-708.
MLA	Tang, Dong-E,et al."Histone Demethylase JMJD1A Promotes Tumor Progression via Activating Snail in Prostate Cancer".MOLECULAR CANCER RESEARCH 18.5(2020):698-708.