南方科技大学知识苑(SUSTech KC): Synthesis of chiral alpha-substituted alpha-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation

题名	Synthesis of chiral alpha-substituted alpha-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation
作者	Liu, Gongyi 1; Zhang, Xianghe 1; Wang, Heng2 ; Cong, Hengjiang 1; Zhang, Xumu1,2 ; Dong, Xiu-Qin 1
通讯作者	Zhang, Xumu; Dong, Xiu-Qin
发表日期	2020-05-04
DOI	10.1039/d0cc01174f
发表期刊	CHEMICAL COMMUNICATIONS 影响因子和分区
ISSN	1359-7345
EISSN	1364-548X
卷号	56 期号:36页码:4934-4937
摘要	Highly efficient Ni-catalyzed asymmetric hydrogenation of cyclic N-sulfonyl ketimino esters was, for the first time, successfully developed, providing various chiral alpha-monosubstituted alpha-amino acid derivatives with excellent results (97-99% yields, 90 to >99% ee). Cyclic N-sulfonyl ketimines were also hydrogenated well to afford chiral amine derivatives with 98-99% yields and 97 to >99% ee. The gram-scale asymmetric hydrogenation was performed well with 85% yield and 99% ee using only 0.2 mol% catalyst.
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR ; EI
语种	英语
重要成果	NI论文
学校署名	通讯
资助项目	Natural Science Foundation of Jiangsu Province[BK20190213] ; Wuhan Morning Light Plan of Youth Science and Technology[2017050304010307] ; Shenzhen Science and Technology Innovation Committee[KQTD20150717103157174]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000532243000017
出版者	ROYAL SOC CHEMISTRY
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：22
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/138067
专题	理学院_化学系深圳格拉布斯研究院
作者单位	1.Wuhan Univ, Suzhou Inst, Coll Chem & Mol Sci,Minist Educ, Key Lab Biomed Polymers,Engn Res Ctr Organosilico, Wuhan 430072, Hubei, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China
通讯作者单位	化学系; 深圳格拉布斯研究院
推荐引用方式 GB/T 7714	Liu, Gongyi,Zhang, Xianghe,Wang, Heng,et al. Synthesis of chiral alpha-substituted alpha-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation[J]. CHEMICAL COMMUNICATIONS,2020,56(36):4934-4937.
APA	Liu, Gongyi,Zhang, Xianghe,Wang, Heng,Cong, Hengjiang,Zhang, Xumu,&Dong, Xiu-Qin.(2020).Synthesis of chiral alpha-substituted alpha-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation.CHEMICAL COMMUNICATIONS,56(36),4934-4937.
MLA	Liu, Gongyi,et al."Synthesis of chiral alpha-substituted alpha-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation".CHEMICAL COMMUNICATIONS 56.36(2020):4934-4937.