Body Mass Dynamics Is Determined by the Metabolic Ohm's Law and Adipocyte-Autonomous Fat Mass Homeostasis

Wang，Guanyu1,2,3,4

2020-06-26

10.1016/j.isci.2020.101176

iScience   影响因子和分区

2589-0042

2589-0042

An ODE model integrating metabolic mechanisms with clinical data reveals an Ohm's law governing lifetime body mass dynamics, where fat and lean tissues are analogous to a parallel nonlinear capacitor and resistor, respectively. The law unexpectedly decouples weight stability (a cell-autonomous property of adipocytes) and weight change (a parabolic trajectory governed by Ohm's law). In middle age, insulin resistance causes fat accumulation to avoid excessive body shrinkage in old age. Moderate middle-age spread is thus natural, not an anomaly caused by hypothalamic defects, as proposed by lipostatic theory. These discoveries provide valuable insights into health care practices such as weight control and health assessment, explain certain observed phenomena, make testable predictions, and may help to resolve major conundrums in the field. The ODE model, which is more comprehensive than Ohm's law, is useful to study metabolism at the detailed microscopic levels.

Biological Sciences Endocrinology Mathematical Biosciences

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[61773196] ; Guangdong Research Funds[2017B030301018][2019B030301001][2020KZDZX1182] ; Shenzhen Research Funds[ZDSYS20140509142721429][JCYJ20170817104740861] ; Shenzhen Peacock Plan[KQTD2016053117035204]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000548234900003

CELL PRESS

2-s2.0-85085332902

Scopus

1.Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China
2.Guangdong Provincial Key Laboratory of Computational Science and Material Design,Shenzhen,518055,China
3.Guangdong Provincial Key Laboratory of Cell Microenviroment and Disease Research,Shenzhen,518055,China
4.Shenzhen Key Laboratory of Cell Microenviroment,Shenzhen,518055,China

Wang，Guanyu. Body Mass Dynamics Is Determined by the Metabolic Ohm's Law and Adipocyte-Autonomous Fat Mass Homeostasis[J]. iScience,2020,23(6).

Wang，Guanyu.(2020).Body Mass Dynamics Is Determined by the Metabolic Ohm's Law and Adipocyte-Autonomous Fat Mass Homeostasis.iScience,23(6).

Wang，Guanyu."Body Mass Dynamics Is Determined by the Metabolic Ohm's Law and Adipocyte-Autonomous Fat Mass Homeostasis".iScience 23.6(2020).