Association of cardiovascular diseases with milk intake among general Chinese adults

Wang，Xin Yan1,2; Liu，Fang Chao1,2; Yang，Xue Li1,2; Li，Jian Xin1,2; Cao，Jie1,2; Lu，Xiang Feng1,2; Huang，Jian Feng1,2; Li，Ying1,2; Chen，Ji Chun1,2; Zhao，Lian Cheng2; Shen，Chong3; Hu，Dong Sheng4,5; Zhao，Ying Xin6; Yu，Ling7; Liu，Xiao Qing8; Wu，Xian Ping9; Gu，Dong Feng1,2,10

2020-05-20

10.1097/CM9.0000000000000786

CHINESE MEDICAL JOURNAL   影响因子和分区

0366-6999

2542-5641

BACKGROUND: The association of milk intake with cardiovascular disease (CVD) and cause-specific mortality remained controversial and evidence among the Chinese population was limited. We aimed to study the relationship between milk intake and CVDs among general Chinese adults. METHODS: A total of 104,957 participants received questionnaire survey. Results of physical examination such as anthropometric measurements and biochemical tests during 2007 to 2008, demographic data and their information on milk intake were collected through standardized questionnaires. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) of CVD incidence, cause-specific mortality and all-cause mortality related to milk intake. Restricted cubic splines (RCSs) were applied to examine dose-response associations. RESULTS: Among the 91,757 participants with a median follow-up period of 5.8 years, we documented 3877 CVD cases and 4091 all-cause deaths. Compared with participants who never consumed milk, the multivariate-adjusted HRs (95% CIs) of CVD incidence for 1 to 150 g/day, 151 to 299 g/day, and ≥300 g/day were 0.94 (0.86-1.03) (P > 0.05), 0.77 (0.66-0.89) (P < 0.05), and 0.59 (0.40-0.89) (P < 0.05), respectively; each 100 g increase of daily milk intake was associated with 11% lower risk of CVD incidence (HR, 0.89; 95% CI: 0.85-0.94; P < 0.001), and 11% lower risk of CVD mortality (HR, 0.89; 95% CI: 0.82-0.97; P = 0.008) after adjustment for age, sex, residential area, geographic region, education level, family history of CVD, smoking, alcohol drinking, physical activity level, body mass index, and healthy diet status (ideal or not). RCS analyses also showed a linear dose-response relationship with CVD (P for overall significance of the curve <0.001; P for non-linearity = 0.979; P for linearity <0.001) and stroke (P for overall significance of the curve = 0.010; P for non-linearity = 0.998; P for linearity = 0.002) incidence, and CVD mortality (P for overall significance of the curve = 0.045; P for non-linearity = 0.768; P for linearity = 0.014) within the current range of daily milk intake. CONCLUSIONS: Daily milk intake was associated with lower risk of CVD incidence and mortality in a linear inverse relationship. The findings provide new evidence for dietary recommendations in CVD prevention among Chinese adults and people with similar dietary pattern in other countries.

Milk Cardiovascular disease Incidence All-cause mortality Cause-specific mortality Prospective study Chinese population

SCI

英语

其他

Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences[2017-I2M-1-004][2019-I2M-2003] ; National Key R&D Program of China[2017YFC0211700][2018YFE0115300] ; National Natural Science Foundation of China[91643208]

General & Internal Medicine

Medicine, General & Internal

WOS:000537784300003

LIPPINCOTT WILLIAMS & WILKINS

CLINICAL MEDICINE

2-s2.0-85085157947

Scopus

1.Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences,100037,China
2.Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,100037,China
3.Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,211166,China
4.Department of Epidemiology and Health Statistics,College of Public Health,Zhengzhou University,Zhengzhou,450001,China
5.Department of Biostatistics and Epidemiology,School of Public Health,Shenzhen University Health Science Center,Shenzhen,China
6.Shandong First Medical University,Jinan,271000,China
7.Department of Cardiology,Fujian Provincial People's Hospital,Fuzhou,350004,China
8.Division of Epidemiology,Guangdong Provincial People's Hospital and Cardiovascular Institute,Guangzhou,510080,China
9.Sichuan Center for Disease Control and Prevention,Chengdu,610041,China
10.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

Wang，Xin Yan,Liu，Fang Chao,Yang，Xue Li,et al. Association of cardiovascular diseases with milk intake among general Chinese adults[J]. CHINESE MEDICAL JOURNAL,2020,133(10):1144-1154.

Wang，Xin Yan.,Liu，Fang Chao.,Yang，Xue Li.,Li，Jian Xin.,Cao，Jie.,...&Gu，Dong Feng.(2020).Association of cardiovascular diseases with milk intake among general Chinese adults.CHINESE MEDICAL JOURNAL,133(10),1144-1154.

Wang，Xin Yan,et al."Association of cardiovascular diseases with milk intake among general Chinese adults".CHINESE MEDICAL JOURNAL 133.10(2020):1144-1154.