南方科技大学知识苑(SUSTech KC): Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis

题名	Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis
作者	Lu，Qingmiao 1; Wang，Mingjie 1; Gui，Yuan 1; Hou，Qing 1; Gu，Mengru 1; Liang，Yan 1; Xiao，Bo2 ; Zhao，Allan Zijian 3; Dai，Chunsun 1
通讯作者	Dai，Chunsun
发表日期	2020-05-01
DOI	10.1038/s41419-020-2539-4
发表期刊	Cell Death & Disease 影响因子和分区
ISSN	2041-4889
EISSN	2041-4889
卷号	11 期号:5
摘要	Ras homolog enriched in brain (Rheb1), a small GTPase, plays a crucial role in regulating cell growth, differentiation, and survival. However, the role and mechanisms for Rheb1 in tubular cell survival and acute kidney injury (AKI) remain unexplored. Here we found that Rheb1 signaling was activated in kidney tubule of AKI patients and cisplatin-treated mice. A mouse model of tubule-specific deletion of Rheb1 (Tubule-Rheb1) was generated. Compared to control littermates, Tubule-Rheb1 mice were phenotypically normal within 2 months after birth but developed more severe kidney dysfunction, tubular cell death including apoptosis, necroptosis and ferroptosis, mitochondrial defect and less PGC-1α expression after cisplatin injection. In primary cultured tubular cells, Rheb1 ablation exacerbated cisplatin-induced cell death and mitochondrial defect. Furthermore, haploinsufficiency for Tsc1 in tubular cells led to Rheb1 activation and mitigated cisplatin-induced cell death, mitochondrial defect and AKI. Together, this study uncovers that Rheb1 may protect against cisplatin-induced tubular cell death and AKI through maintaining mitochondrial homeostasis.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS记录号	WOS:000536504700004
Scopus记录号	2-s2.0-85084546190
来源库	Scopus
引用统计	被引频次[WOS]：45
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/138214
专题	生命科学学院_生物系生命科学学院
作者单位	1.Center for Kidney Disease,2nd Affiliated Hospital,Nanjing Medical University,Nanjing,262 North Zhongshan Road,China 2.Department of Biology,Southern University of Science and Technology,Shenzhen,518000,China 3.Institute of Biomedical and Pharmaceutical Sciences,Guangdong University of Technology,Guangzhou,510515,China
推荐引用方式 GB/T 7714	Lu，Qingmiao,Wang，Mingjie,Gui，Yuan,et al. Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis[J]. Cell Death & Disease,2020,11(5).
APA	Lu，Qingmiao.,Wang，Mingjie.,Gui，Yuan.,Hou，Qing.,Gu，Mengru.,...&Dai，Chunsun.(2020).Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis.Cell Death & Disease,11(5).
MLA	Lu，Qingmiao,et al."Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis".Cell Death & Disease 11.5(2020).