Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication

Song，Shihao1,2; Yin，Wenfang1; Sun，Xiuyun1,2; Cui，Binbin2; Huang，Lei2; Li，Peng3; Yang，Liang4; Zhou，Jianuan1; Deng，Yinyue2

2020

10.1038/s41396-020-0682-7

ISME Journal   影响因子和分区

1751-7362

1751-7370

Quorum sensing (QS) signals are widely utilized by bacteria to regulate biological functions in response to cell population density. Previous studies have demonstrated that Ralstonia solanacearum employs two different types of QS systems. We report here that anthranilic acid controls important biological functions and the production of QS signals in R. solanacearum. It was demonstrated that the biosynthesis of anthranilic acid is mainly performed by TrpEG. The accumulation of anthranilic acid and the transcription of trpEG occur in a cell density-dependent manner in R. solanacearum. Both the anthranilic acid and TrpEG homologues are conserved in various bacterial species. Moreover, we show that Sporisorium scitamineum sexual mating and hypha formation are strongly inhibited by the addition of exogenous anthranilic acid. Our results suggest that anthranilic acid is important for the physiology of bacteria in addition to its role in inter-kingdom communication.

SCI

英语

NI论文

其他

China National Natural Science Foundation[31571969] ; Guangdong Natural Science Funds for Distinguished Young Scholars, China[2014A030306015]

Environmental Sciences & Ecology ; Microbiology

Ecology ; Microbiology

WOS:000539443900001

NATURE PUBLISHING GROUP

2-s2.0-85086365724

Scopus

1.College of Agriculture,South China Agricultural University,Guangzhou,510642,China
2.School of Pharmaceutical Sciences (Shenzhen),Sun Yat-sen University,Guangzhou,510275,China
3.Ministry of Education Key Laboratory for Ecology of Tropical Islands,College of Life Sciences,Hainan Normal University,Haikou,571158,China
4.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

Song，Shihao,Yin，Wenfang,Sun，Xiuyun,et al. Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication[J]. ISME Journal,2020,14(9):2248-2260.

Song，Shihao.,Yin，Wenfang.,Sun，Xiuyun.,Cui，Binbin.,Huang，Lei.,...&Deng，Yinyue.(2020).Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication.ISME Journal,14(9),2248-2260.

Song，Shihao,et al."Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication".ISME Journal 14.9(2020):2248-2260.