In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter

Wang，Dou1,2; Ge，Chenchen1,3; Liang，Weiyuan4; Yang，Qinhe5; Liu，Quan1,3; Ma，Wei1; Shi，Lulin1; Wu，Hong1; Zhang，Yuhua1; Wu，Zongze1; Wei，Chaoying1; Huang，Luodan1; Fang，Zhiyuan6; Liu，Liping1; Bao，Shiyun1; Zhang，Han4

2020

10.1002/advs.202000940

Advanced Science   影响因子和分区

2198-3844

2198-3844

The circulating tumor cell (CTC) count is closely related to cancer recurrence and metastasis. The technology that can in vivo destroy CTCs may bring great benefits to patients, which is an urgent clinical demand. Here, a minimally invasive therapeutic intravenous catheter for in vivo enriching and photothermal killing of CTCs is developed. The surface of catheter is modified with anti-EpCAM antibody and the interior is filled with black phosphorus nanosheets (BPNSs). CTCs in the peripheral blood are captured by the catheter continually with the aid of circulation. The captured CTCs are used for downstream analyses or in vivo eliminated by the near-infrared (NIR) photothermal effect of BPNSs. A capture efficiency of 2.1% is obtained during the 5 min of treatment, and 100% of the captured CTCs are killed by following NIR light irradiation in both an in vitro closed-loop circulation system and an in vivo rabbit model. This cost-effective modality for lowering the CTCs burden can be a good supplement to traditional therapies, which holds great promise as an effective clinical intervention for cancer patients.

black phosphorus circulating tumor cells EpCAM intravenous catheters photothermal therapy

SCI ; EI

英语

其他

State Key Research Development Program of China[2019YFB2203503]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000539586500001

WILEY

20202408818782

Catheters ; Cost effectiveness ; Patient treatment ; Tumors ; Diseases ; Infrared devices ; Phosphorus

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Biomedical Equipment, General:462.1 ; Chemical Products Generally:804 ; Industrial Economics:911.2

2-s2.0-85086276791

Scopus

1.Department of Hepatobiliary and Pancreatic Surgery,The 2nd Clinical medical College (Shenzhen People's Hospital) of Jinan University,Shenzhen,518020,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Integrated Chinese and Western Medicine Postdoctoral research station,Jinan University,Guangzhou,510632,China
4.Shenzhen Second People's Hospital,The First Affiliated Hospital of Shenzhen University and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,Shenzhen University,Shenzhen,518060,China
5.School of Traditional Chinese Medicine,Jinan University,Guangzhou,510632,China
6.School of Biomedical and Pharmaceutical Sciences,Guangdong University of Technology,Guangzhou,510006,China

Wang，Dou,Ge，Chenchen,Liang，Weiyuan,et al. In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter[J]. Advanced Science,2020,7(17).

Wang，Dou.,Ge，Chenchen.,Liang，Weiyuan.,Yang，Qinhe.,Liu，Quan.,...&Zhang，Han.(2020).In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter.Advanced Science,7(17).

Wang，Dou,et al."In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter".Advanced Science 7.17(2020).