南方科技大学知识苑(SUSTech KC): Human neutralizing antibodies elicited by SARS-CoV-2 infection

题名	Human neutralizing antibodies elicited by SARS-CoV-2 infection
作者	Ju，Bin 1,2; Zhang，Qi 3; Ge，Jiwan 4; Wang，Ruoke 3; Sun，Jing 5; Ge，Xiangyang 1; Yu，Jiazhen 1; Shan，Sisi 3; Zhou，Bing 1; Song，Shuo 1; Tang，Xian 1; Yu，Jinfang 4; Lan，Jun 4; Yuan，Jing 6; Wang，Haiyan 1; Zhao，Juanjuan 1,2; Zhang，Shuye 7; Wang，Youchun 8; Shi，Xuanling 3; Liu，Lei 1,2 ; Zhao，Jincun 5; Wang，Xinquan 4; Zhang，Zheng 1,2 ; Zhang，Linqi 3
通讯作者	Zhang，Zheng
发表日期	2020
DOI	10.1038/s41586-020-2380-z
发表期刊	NATURE 影响因子和分区
ISSN	0028-0836
EISSN	1476-4687
卷号	584 期号:7819页码:115-+
摘要	The emerging coronavirus SARS-CoV-2 pandemic presents a global health emergency in urgent need of interventions. SARS-CoV-2 entry into the target cells depends on binding between the receptor-binding domain (RBD) of the viral Spike protein and the ACE2 cell receptor. Here, we report the isolation and characterization of 206 RBD-specific monoclonal antibodies derived from single B cells of eight SARS-CoV-2 infected individuals. We identified antibodies with potent anti-SARS-CoV-2 neutralization activity that correlates with their competitive capacity with ACE2 for RBD binding. Surprisingly, neither the anti-SARS-CoV-2 antibodies nor the infected plasma cross-reacted with SARS-CoV or MERS-CoV RBDs, although substantial plasma cross-reactivity to their trimeric Spike proteins was found. Crystal structure analysis of RBD-bound antibody revealed steric hindrance that inhibits viral engagement with ACE2 and thereby blocks viral entry. These findings suggest that anti-RBD antibodies are viral species-specific inhibitors. The antibodies identified here may be candidates for the development of SARS-CoV-2 clinical interventions.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
重要成果	NI论文 ; ESI高被引
学校署名	通讯
资助项目	Science and Technology Innovation Committee of Shenzhen Municipality[202002073000002] ; Tsinghua University Initiative Scientific Research Program[20201080053] ; National Beijing Municipal Science and Technology Commission[171100000517-001][171100000517-003] ; National Key Plan for Scientific Research and Development of China[2016YFD0500307]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000554511300002
出版者	NATURE PUBLISHING GROUP
ESI学科分类	BIOLOGY & BIOCHEMISTRY;CLINICAL MEDICINE;MULTIDISCIPLINARY;PLANT & ANIMAL SCIENCE;ENVIRONMENT/ECOLOGY;SOCIAL SCIENCES, GENERAL;MICROBIOLOGY;ECONOMICS BUSINESS;IMMUNOLOGY;MATERIALS SCIENCE;COMPUTER SCIENCE;SPACE SCIENCE;MOLECULAR BIOLOGY & GENETICS;CHEMISTRY;NEUROSCIENCE & BEHAVIOR;PHYSICS;GEOSCIENCES;ENGINEERING
Scopus记录号	2-s2.0-85085949737
来源库	Scopus
引用统计	被引频次[WOS]：1006
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/140054
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,Shenzhen,518112,China 2.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China 3.Center for Global Health and Infectious Diseases,Comprehensive AIDS Research Center,and Beijing Advanced Innovation Center for Structural Biology,School of Medicine,Tsinghua University,Beijing,100084,China 4.The Ministry of Education Key Laboratory of Protein Science,Beijing Advanced Innovation Center for Structural Biology,Beijing Frontier Research Center for Biological Structure,Collaborative Innovation Center for Biotherapy,School of Life Sciences,Tsinghua University,Beijing,100084,China 5.State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510182,China 6.Department for Infectious Diseases,Shenzhen Third People’s Hospital,Shenzhen,518112,China 7.Shanghai Public Health Clinical Center and Institute of Biomedical Sciences,Fudan University,Shanghai,201508,China 8.Division of HIV/AIDS and Sex-Transmitted Virus Vaccines,National Institutes for Food and Drug Control,Beijing,China
第一作者单位	南方科技大学医学院; 南方科技大学第二附属医院
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Ju，Bin,Zhang，Qi,Ge，Jiwan,et al. Human neutralizing antibodies elicited by SARS-CoV-2 infection[J]. NATURE,2020,584(7819):115-+.
APA	Ju，Bin.,Zhang，Qi.,Ge，Jiwan.,Wang，Ruoke.,Sun，Jing.,...&Zhang，Linqi.(2020).Human neutralizing antibodies elicited by SARS-CoV-2 infection.NATURE,584(7819),115-+.
MLA	Ju，Bin,et al."Human neutralizing antibodies elicited by SARS-CoV-2 infection".NATURE 584.7819(2020):115-+.