南方科技大学知识苑(SUSTech KC): Effect of aspirin on PET parameters in primary non-small cell lung cancer and its relationship with prognosis

题名	Effect of aspirin on PET parameters in primary non-small cell lung cancer and its relationship with prognosis
作者	Chen, Jinghua 1,2,3; Xia, Junxian 1,2,3; Huang, Jiacheng 1,2,3; Xu, Ruilian 1,2,3
通讯作者	Xu, Ruilian
发表日期	2020-06-03
DOI	10.1186/s12885-020-06983-2
发表期刊	BMC CANCER 影响因子和分区
ISSN	1471-2407
EISSN	1471-2407
卷号	20 期号:1
摘要	Background18 F-FDG is a glucose analogue whose metabolic index SUV can effectively reflect the metabolic level of tumor microenvironment. Aspirin can affect the uptake of 18F-FDG by cancer cells, reducing the SUVmax value of primary tumors, exerting antitumor effect. This study aimed to evaluate the prognostic value of long-term aspirin and the relationship between aspirin intake and PET parameters value of primary tumor in non-small cell lung cancer (NSCLC).MethodsEighty-one NSCLC patients were recruited and divided into two groups: aspirin medication group and control group, who underwent surgery and had pathological diagnosis data between January 2012 and December 2016. Clinical characteristics were retrospective analyzed to evaluate the possibility of clinical prognosis, respectively. Kaplan-Meier curves and a Cox proportional hazard model were applied to evaluate the predictors of prognosis.ResultsThe PET/CT SUVmax of the primary tumor in the aspirin group was lower than that in the control group (P<0.05). Compared with the control group, the SUVmax, SUVmean and TLG of the primary tumor in aspirin group were lower, but the MTV value had no significant difference. Cox regression analysis showed that N stage and TNM stage were predictors of the prognosis. There was a significant difference in the use of aspirin in NSCLC patients.ConclusionAspirin can reduce SUVmax, SUVmean and TLG in primary tumor and aspirin can improve the prognosis of patients with NSCLC.
关键词	Aspirin SUVmax 18F-FDG Non-small cell lung cancer Prognosis
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Science, Technology & Innovation Commission of Shenzhen Municipality[JCYJ20160422144516003]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000540050300005
出版者	BMC
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/140295
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China 2.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China 3.Shenzhen Peoples Hosp, Dept Med Oncol, Shenzhen 518020, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Chen, Jinghua,Xia, Junxian,Huang, Jiacheng,et al. Effect of aspirin on PET parameters in primary non-small cell lung cancer and its relationship with prognosis[J]. BMC CANCER,2020,20(1).
APA	Chen, Jinghua,Xia, Junxian,Huang, Jiacheng,&Xu, Ruilian.(2020).Effect of aspirin on PET parameters in primary non-small cell lung cancer and its relationship with prognosis.BMC CANCER,20(1).
MLA	Chen, Jinghua,et al."Effect of aspirin on PET parameters in primary non-small cell lung cancer and its relationship with prognosis".BMC CANCER 20.1(2020).