First case of COVID-19 complicated with fulminant myocarditis: a case report and insights

Zeng, Jia-Hui1; Liu, Ying-Xia2; Yuan, Jing3; Wang, Fu-Xiang3; Wu, Wei-Bo3; Li, Jin-Xiu4; Wang, Li-Fei5; Gao, Hong6; Wang, Yao1; Dong, Chang-Feng1; Li, Yi-Jun1; Xie, Xiao-Juan1; Feng, Cheng1; Liu, Lei2

2020-04-10

10.1007/s15010-020-01424-5

INFECTION   影响因子和分区

0300-8126

1439-0973

Background Coronavirus disease 2019 (COVID-19) has been demonstrated to be the cause of pneumonia. Nevertheless, it has not been reported as the cause of acute myocarditis or fulminant myocarditis. Case presentation A 63-year-old male was admitted with pneumonia and cardiac symptoms. He was genetically confirmed as having COVID-19 according to sputum testing on the day of admission. He also had elevated troponin I (Trop I) level (up to 11.37 g/L) and diffuse myocardial dyskinesia along with a decreased left ventricular ejection fraction (LVEF) on echocardiography. The highest level of interleukin-6 was 272.40 pg/ml. Bedside chest radiographs showed typical ground-glass changes indicative of viral pneumonia. Laboratory test results for viruses that cause myocarditis were all negative. The patient conformed to the diagnostic criteria of the Chinese expert consensus statement for fulminant myocarditis. After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. Moreover, the LVEF of the patient gradually recovered to 68%. The patient died of aggravation of secondary infection on the 33rd day of hospitalization. Conclusion COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. This is the first report of COVID-19 complicated with fulminant myocarditis. The mechanism of cardiac pathology caused by COVID-19 needs further study.

COVID-19 Coronavirus Fulminant myocarditis Infection Echocardiography

SCI

英语

ESI高被引

第一 ; 通讯

Infectious Diseases

Infectious Diseases

WOS:000539134900001

SPRINGER HEIDELBERG

IMMUNOLOGY

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2,Dept Med Ultrason, Natl Clin Res Ctr Infect Dis,State Key Discipline, 29 Bulan Rd, Shenzhen 518112, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2,Dept Infect Dis, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2,Dept Intens Care Unit, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen, Peoples R China
5.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2,Dept Radiol, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen, Peoples R China
6.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2,Dept Cardiol, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen, Peoples R China

Zeng, Jia-Hui,Liu, Ying-Xia,Yuan, Jing,et al. First case of COVID-19 complicated with fulminant myocarditis: a case report and insights[J]. INFECTION,2020,48(5):773-777.

Zeng, Jia-Hui.,Liu, Ying-Xia.,Yuan, Jing.,Wang, Fu-Xiang.,Wu, Wei-Bo.,...&Liu, Lei.(2020).First case of COVID-19 complicated with fulminant myocarditis: a case report and insights.INFECTION,48(5),773-777.

Zeng, Jia-Hui,et al."First case of COVID-19 complicated with fulminant myocarditis: a case report and insights".INFECTION 48.5(2020):773-777.