Effects of alginate/chondroitin sulfate-based hydrogels on bone defects healing

Fenbo，Ma1; Sijing，Li1,4; Ruiz-Ortega，L. I.1; Yuanjun，Zhang1; Lei，Xu1; Kui，Wang1; Lijun，Lin4; Bin，Tang1,2,3

2020-11-01

10.1016/j.msec.2020.111217

Materials Science & Engineering C-Materials for Biological Applications   影响因子和分区

0928-4931

1873-0191

Repairing bone defects remains challenging in orthopedics. Here, strontium (Sr) alginate hydrogels containing chondroitin sulfate (CS) were fabricated for enhancing bone defects repair. The effects of CS incorporation ratio on the morphology, structure, thermal stability, water uptake and mechanical performance of Sr-CS/alginate hydrogels were also evaluated. Increasing CS incorporation ratio, Sr-CS/alginate hydrogels exhibit decreasing mechanical properties and lower water retention capacity. In vitro results suggest that Sr-CS/alginate hydrogels with higher CS ratio facilitate the proliferation of osteoblasts. Additionally, the osteogenic genes expressions were investigated by real-time quantitative polymerase chain reaction (RT-qPCR). The results reveal that Sr-CS/alginate hydrogels should have positive effects on modulating the osteogenic factors. Moreover, by employing repair femoral cylindrical defects rabbit model, the efficiency of as-fabricated Sr-CS/alginate hydrogels in bone regeneration was evaluated. The animal study suggests that Sr-CS/alginate hydrogel could significantly facilitate bone defects repair and therefore should potentially be useful for osteochondral tissue engineering.

Bone defects Chondroitin sulfate Hydrogel Osteoblasts

SCI ; EI

英语

第一 ; 通讯

National Foundation of Science and Technology[11872200] ; Guangdong Foundation of Science and Technology[2017B030301018] ; Shenzhen Science and Technology Innovation Committee[JCYJ20160517160827379][JCYJ20170817111312887][GRCK20160829195523424][ZDSYS20140509142721429]

Materials Science

Materials Science, Biomaterials

WOS:000563473200004

ELSEVIER

20202608874839

Defects ; Tissue engineering ; Bone ; Polymerase chain reaction ; Repair ; Sulfur compounds

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biochemistry:801.2 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Maintenance:913.5 ; Materials Science:951

2-s2.0-85086822180

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,China
2.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,China
3.Shenzhen Key Laboratory of Cell Microenvironment,China
4.Department of Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou,China

Fenbo，Ma,Sijing，Li,Ruiz-Ortega，L. I.,et al. Effects of alginate/chondroitin sulfate-based hydrogels on bone defects healing[J]. Materials Science & Engineering C-Materials for Biological Applications,2020,116.

Fenbo，Ma.,Sijing，Li.,Ruiz-Ortega，L. I..,Yuanjun，Zhang.,Lei，Xu.,...&Bin，Tang.(2020).Effects of alginate/chondroitin sulfate-based hydrogels on bone defects healing.Materials Science & Engineering C-Materials for Biological Applications,116.

Fenbo，Ma,et al."Effects of alginate/chondroitin sulfate-based hydrogels on bone defects healing".Materials Science & Engineering C-Materials for Biological Applications 116(2020).