Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics

Wang，Le1; Wang，Le2; Natan，Michal3; Zheng，Wenshu2; Zheng，Wenfu2; Zheng，Wenfu4; Liu，Shaoqin1; Jacobi，Gila3; Perelshtein，Ilana5; Gedanken，Aharon5; Banin，Ehud3; Jiang，Xingyu2; Jiang，Xingyu6

2020-06-01

10.1039/d0na00179a

Nanoscale Advances   影响因子和分区

2516-0230

2516-0230

The increase in antibiotic resistance reported worldwide poses an immediate threat to human health and highlights the need to find novel approaches to inhibit bacterial growth. In this study, we present a series of gold nanoparticles (Au NPs) capped by different N-heterocyclic molecules (N_Au NPs) which can serve as broad-spectrum antibacterial agents. Neither the Au NPs nor N-heterocyclic molecules were toxic to mammalian cells. These N_Au NPs can attach to the surface of bacteria and destroy the bacterial cell wall to induce cell death. Sonochemistry was used to coat Au NPs on the surface of fabrics, which showed superb antimicrobial activity against multi-drug resistant (MDR) bacteria as well as excellent efficacy in inhibiting bacterial biofilms produced by MDR bacteria. Our study provides a novel strategy for preventing the formation of MDR bacterial biofilms in a straightforward, low-cost, and efficient way, which holds promise for broad clinical applications.

ESCI ; EI

英语

其他

National Natural Science Foundation of China[21761142006][21535001][81730051][81673039] ; National Key R&D Program of China[2017YFA0205901][2018YFA0902600] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039][121D11KYSB20170026][XDA16020902] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191] ; ISF-NSCF[2542/17]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000543283200008

ROYAL SOC CHEMISTRY

20202608870751

Cell death ; Biofilms ; Drug delivery ; Bacteria ; Cell membranes ; Health risks ; Metal nanoparticles ; Fiber optic sensors ; Molecules ; Organic compounds ; Mammals

Biological Materials and Tissue Engineering:461.2 ; Health Care:461.7 ; Biology:461.9 ; Biomaterials (including synthetics):462.5 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Organic Compounds:804.1 ; Atomic and Molecular Physics:931.3

2-s2.0-85086804532

Scopus

1.School of Life Science and Technology,Harbin Institute of Technology,Nangang District, Harbin,2 Yikuang Road,150001,China
2.Beijing Engineering Research Center for BioNanotechnology,CAS,Key Laboratory for Biological Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology,Beijing,100190,China
3.Institute for Advanced Materials and Nanotechnology,Mina and Everard Goodman Faculty of Life Sciences,Bar-Ilan University,Ramat-Gan,52900,Israel
4.GBA Research Innovation Institute for Nanotechnology,Guangdong,510700,China
5.Institute for Advanced Materials and Nanotechnology,Department of Chemistry,Bar-Ilan University,Ramat Gan,5290002,Israel
6.Department of Biomedical Engineering,Southern University of Science and Technology,Nanshan District, Shenzhen, Guangdong,No. 1088 Xueyuan Rd,518055,China

Wang，Le,Wang，Le,Natan，Michal,et al. Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics[J]. Nanoscale Advances,2020,2(6):2293-2302.

Wang，Le.,Wang，Le.,Natan，Michal.,Zheng，Wenshu.,Zheng，Wenfu.,...&Jiang，Xingyu.(2020).Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics.Nanoscale Advances,2(6),2293-2302.

Wang，Le,et al."Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics".Nanoscale Advances 2.6(2020):2293-2302.