Rapid Fabrication of Self-Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body

Li，Sixiang1,2; Wang，Le2; Zheng，Wenfu3; Yang，Guang1; Jiang，Xingyu2

2020

10.1002/adfm.202002370

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Skin wounds on stretchable parts of the body including the elbows, knees, wrists, and nape usually undergo delayed and poor healing due to the interference of their frequent motion. Ordinary dressings that are not flexible enough face difficulty to promote wound healing due to the mismatching between the mechanics of the dressing materials and the wounds. In this study, an injectable, biocompatible, self-healable, and conductive material poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate)/guar slime (PPGS) is developed for healing wounds with various kinds of movements. As a proof-of-principle assay, the healing effect of PPGS is explored on a skin wound model on the nape of rats that often experiences frequent movements. PPGS, which can be prepared within 1 min, successfully accelerates the healing of the wounds. The results suggest that PPGS has great potential in the fields of tissue engineering and biomedicine.

conductive hydrogels guar gum self-healing stretchable wounds wound healing

SCI ; EI

英语

NI论文 ; ESI高被引

其他

National Natural Science Foundation of China[21574050][51603079][21535001][21774039][81730051][21761142006][81673039] ; National Key R&D Program of China[2018YFA0902600][2017YFA0205901] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039][121D11KYSB20170026][XDA16020902] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000540738800001

WILEY-V C H VERLAG GMBH

20202508849376

Biocompatibility ; Self-healing materials ; Tissue engineering

Metals, Plastics, Wood and Other Structural Materials:415 ; Biomedical Engineering:461.1 ; Immunology:461.9.1 ; Conducting Materials:708.2

MATERIALS SCIENCE

2-s2.0-85086520763

Scopus

1.Department of Biomedical Engineering,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,No. 1037 Luoyu Rd, Hongshan District,430074,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District,518055,China
3.GBA Research Innovation Institute for Nanotechnology,Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for NanoScience and Technology,University of Chinese Academy of Sciences,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China

Li，Sixiang,Wang，Le,Zheng，Wenfu,et al. Rapid Fabrication of Self-Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body[J]. ADVANCED FUNCTIONAL MATERIALS,2020,30(31).

Li，Sixiang,Wang，Le,Zheng，Wenfu,Yang，Guang,&Jiang，Xingyu.(2020).Rapid Fabrication of Self-Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body.ADVANCED FUNCTIONAL MATERIALS,30(31).

Li，Sixiang,et al."Rapid Fabrication of Self-Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body".ADVANCED FUNCTIONAL MATERIALS 30.31(2020).