Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

Liu, Yingxia1; Zhang, Cong2,3; Huang, Fengming4; Yang, Yang1; Wang, Fuxiang1; Yuan, Jing1; Zhang, Zheng1; Qin, Yuhao4; Li, Xiaoyun4; Zhao, Dandan4; Li, Shunwang4; Tan, Shuguang5; Wang, Zhaoqin1; Li, Jinxiu1; Shen, Chenguang1; Li, Jianming1; Peng, Ling1; Wu, Weibo1; Cao, Mengli1; Xing, Li1; Xu, Zhixiang1; Chen, Li1; Zhou, Congzhao2,3; Liu, William J.5; Liu, Lei1; Jiang, Chengyu4

2020-06

10.1093/nsr/nwaa037

National Science Review   影响因子和分区

2095-5138

2053-714X

A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with 2019-nCoV infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-nCoV, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-nCoV-infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-alpha 2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-gamma, IL-1 alpha, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of 2019-nCoV infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-nCoV infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.

2019-nCoV COVID-19 cytokine storm IP-10 IL-17

SCI ; EI

英语

ESI高被引

第一 ; 通讯

National Natural Science Foundation of China[81788101] ; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences[2017-12M-1-009] ; Ministry of Science and Technology[2020YFC0846300] ; National Science and Technology Major Project[2018ZX10711001] ; Shenzhen Science and Technology Research and Development Project[202002073000001]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000544175300009

OXFORD UNIV PRESS

20203609132707

Biological organs ; Blood ; Coronavirus

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Health Care:461.7

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun, State Key Discipline Infect Dis,Hosp 2, Shenzhen Peoples Hosp 3,Natl Clin Res Ctr Infect, Shenzhen 518112, Peoples R China
2.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China
4.Chinese Acad Med Sci, Dept Biochem, Peking Union Med Coll, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
5.China CDC, Natl Inst Viral Dis Control & Prevent, NHC Key Lab Biosafety, Beijing 102206, Peoples R China

Liu, Yingxia,Zhang, Cong,Huang, Fengming,et al. Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury[J]. National Science Review,2020,7(6):1003-1011.

Liu, Yingxia.,Zhang, Cong.,Huang, Fengming.,Yang, Yang.,Wang, Fuxiang.,...&Jiang, Chengyu.(2020).Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury.National Science Review,7(6),1003-1011.

Liu, Yingxia,et al."Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury".National Science Review 7.6(2020):1003-1011.