An All-Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging-Guided Synergistic Therapy

Zhang, Zhijun1,2; Xu, Wenhan3; Kang, Miaomiao1,2; Wen, Haifei1; Guo, Heng4; Zhang, Pengfei5; Xi, Lei4; Li, Kai4; Wang, Lei1; Wang, Dong1; Tang, Ben Zhong3

2020-07-21

10.1002/adma.202003210

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, the optimum use of dissipated energy through both radiative and nonradiative pathways is definitely appealing, yet a significantly challenging task. To the best of the knowledge, there have been no previous reports on a single molecular species effective at affording all phototheranostic modalities including fluorescence imaging (FLI), photoacoustic imaging (PAI), photothermal imaging (PTI), photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, a simple and highly powerful one-for-all phototheranostics based on aggregation-induced emission (AIE)-active fluorophores is tactfully designed and constructed. Thanks to its strong electron donor-acceptor interaction and finely modulated intramolecular motion, the AIE fluorophore-based nanoparticles simultaneously exhibit bright near-infrared II (NIR-II) fluorescence emission, efficient reactive oxygen species generation, and high photothermal conversion efficiency upon NIR irradiation, indicating the actualization of a balance between radiative and nonradiative energy dissipations. Furthermore, the unprecedented performance on NIR-II FLI-PAI-PTI trimodal-imaging-guided PDT-PTT synergistic therapy is demonstrated by the precise tumor diagnosis and complete tumor elimination outcomes. This study thus brings a new insight into the development of superior versatile phototheranostics for practical cancer theranostics.

aggregation-induced emission molecular design NIR-II emission reconciled photophysical properties versatile phototheranostics

SCI ; EI

英语

NI论文 ; ESI高被引

其他

Natural Science Foundation of China[51903163][21801169] ; Natural Science Foundation for Distinguished Young Scholars of Guangdong Province[2020B1515020011] ; Science and Technology Foundation of Shenzhen City[JCYJ20190808153415062] ; Natural science foundation of Shenzhen University[2019004]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000550670700001

WILEY-V C H VERLAG GMBH

20203008973530

Photodynamic therapy ; Diagnosis ; Fluorophores ; Tumors ; Energy dissipation ; Infrared devices

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Energy Losses (industrial and residential):525.4 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Physical Chemistry:801.4

MATERIALS SCIENCE

Web of Science

1.Shenzhen Univ, Coll Mat Sci & Engn, Ctr AIE Res, Shenzhen 518060, Peoples R China
2.Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen 518060, Peoples R China
3.Hong Kong Univ Sci & Technol, Dept Chem, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
5.Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

Zhang, Zhijun,Xu, Wenhan,Kang, Miaomiao,et al. An All-Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging-Guided Synergistic Therapy[J]. ADVANCED MATERIALS,2020,32(36).

Zhang, Zhijun.,Xu, Wenhan.,Kang, Miaomiao.,Wen, Haifei.,Guo, Heng.,...&Tang, Ben Zhong.(2020).An All-Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging-Guided Synergistic Therapy.ADVANCED MATERIALS,32(36).

Zhang, Zhijun,et al."An All-Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging-Guided Synergistic Therapy".ADVANCED MATERIALS 32.36(2020).