| 题名 | Exosomal secretion may be a self-protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone |
| 作者 | |
| 通讯作者 | Fang, Daokui; Hu, Dalin |
| 发表日期 | 2020-07-28
|
| DOI | |
| 发表期刊 | |
| ISSN | 0260-437X
|
| EISSN | 1099-1263
|
| 摘要 | Accumulating evidence reveals that exosome plays an important role in cell-to-cell communication in both physiological and pathological processes by transferring bioactive molecules. However, the role of exosomal secretion in the adaption of its source cells to the stimuli of environmental chemicals remains elusive. In this study, we revealed that the exposure of hydroquinone (HQ; the main bioactive metabolite of benzene) to human bronchial epithelial cells (16HBE) resulted in decreased ability of cell proliferation and migration, and simultaneously DNA damage and micronuclei formation. Interestingly, when exosomal secretion of HQ treated 16HBE cells was inhibited with the inhibitor GW4869, cellular proliferation and migration were further significantly reduced; concurrently, their DNA damage and micronuclei formation were both further significantly aggravated. Herein, we conclude that exosomal secretion of 16HBE cells may be an important self-protective function against the toxic effects induced by HQ. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 其他
|
| 资助项目 | Science and Technology Project of Shenzhen City[JCYJ20170306162947321]
; Guangzhou Municipal Science and Technology Project[201803030027]
; National Natural Science Foundation of China[21677066]
|
| WOS研究方向 | Toxicology
|
| WOS类目 | Toxicology
|
| WOS记录号 | WOS:000552958300001
|
| 出版者 | |
| ESI学科分类 | PHARMACOLOGY & TOXICOLOGY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：9
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/141356 |
| 专题 | 南方科技大学医院 |
| 作者单位 | 1.Shiyan Inst Prevent Med & Hlth Care, Shenzhen, Peoples R China 2.Southern Med Univ, Sch Publ Hlth, Dept Environm Hlth, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Peoples R China 3.Southern Univ Sci & Technol Hosp, Dept Rehabil Med, Shenzhen, Peoples R China 4.Jiamusi Univ, Dept Clin Med, Jiamusi, Peoples R China 5.Ctr Dis Control & Prevent Shenzhen City, Dept Environm Hlth, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 |
He, Zhonghan,Li, Yanfeng,Lian, Zhenwei,et al. Exosomal secretion may be a self-protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone[J]. JOURNAL OF APPLIED TOXICOLOGY,2020.
|
| APA |
He, Zhonghan.,Li, Yanfeng.,Lian, Zhenwei.,Liu, Jin.,Xian, Hongyi.,...&Hu, Dalin.(2020).Exosomal secretion may be a self-protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone.JOURNAL OF APPLIED TOXICOLOGY.
|
| MLA |
He, Zhonghan,et al."Exosomal secretion may be a self-protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone".JOURNAL OF APPLIED TOXICOLOGY (2020).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
;
修改评论