In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes

Yao，Qing1; Parvez-Khan，Mohd2; Schipani，Ernestina2

2020-11-01

10.1016/j.bone.2020.115572

BONE   影响因子和分区

8756-3282

1873-2763

Hypoxia occurs not only in pathological conditions like cancer and ischemia and in a variety of physiological settings in the adult organism, but also during normal embryonic development. In the inner portion of the fetal growth plate, which is an avascular tissue originating from mesenchymal progenitor cells, chondrocytes experience physiological hypoxia. Hypoxia-Inducible Transcription Factor-1α (HIF1α), a crucial mediator of cellular adaptation to hypoxia, is an essential survival factor for fetal growth plate chondrocytes. This brief review summarizes our current understanding of the survival function of HIF1α during endochondral bone development.

Cell survival Chondrocyte Growth plate HIF1α Hypoxia Mitochondrial respiration

SCI

英语

第一

National Institutes of Health[R01 AR074079]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000573433100001

ELSEVIER SCIENCE INC

CLINICAL MEDICINE

2-s2.0-85089276825

Scopus

1.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment and School of Medicine,Southern University of Science and Technology,Shenzhen,1088 Xue Yuan Road,518055,China
2.Departments of Orthopaedic Surgery,Medicine,and Cell and Developmental Biology,University of Michigan School of Medicine,Ann Arbor,48109,United States

Yao，Qing,Parvez-Khan，Mohd,Schipani，Ernestina. In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes[J]. BONE,2020,140.

Yao，Qing,Parvez-Khan，Mohd,&Schipani，Ernestina.(2020).In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes.BONE,140.

Yao，Qing,et al."In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes".BONE 140(2020).