聚醚醚酮/聚乳酸复合的生物医用支架研究

RESEARCH ON POLY ETHER ETHER KETONE/ POLYLACTIC ACID COMPOSITE BIOMEDICAL SCAFFOLD

梁新宇

11849003

硕士

生物医学工程

唐斌

2020-06-04

2020-06-08

哈尔滨工业大学

深圳

聚醚醚酮（PEEK）由于其优良的机械性能、与人体骨骼接近的弹性模量、耐磨性、良好的生物相容性、可被射线穿透等性质成为一种有潜力的骨科植入材料。单纯的聚醚醚酮生物活性较差，化学惰性导致了对其复合改性的方法较为复杂。而另一种应用广泛的可植入生物材料聚乳酸（PLA）的改性研究较为成熟，但是其易脆性断裂、降解周期难以控制等缺点限制了其应用。聚乳酸和聚醚醚酮的复合可以同时弥补各自缺点，充分发挥两者的性能优势，从而开发一种具有优良性能、且容易改性的可植入的骨科修复生物支架材料。

Polyetheretherketone(PEEK) is a promising orthopedic implant material due to its superior mechanical properties and its elastic modulus is comparable to human bone. PEEK is abrasion resistant with outstanding biocompatibility and excellent radiolucency. Pure PEEK has poor bioactivity that needs to be improved, but its chemical inertness leads to complicated modification methods. Polylactic acid(PLA), another widely used implantable biomaterial, has more developed methods of modification, but its brittle fracture, uncontrollable degradation cycle and some other shortcomings limited its application. The combination of PEEK and PLA can avoid shortcomings and take advantage of their prominent performance at the same time. This hybrid material developed to an implantable composite scaffold with excellent properties can be easily modified for application in orthopedic implantation.

聚醚醚酮 聚乳酸 生物医用支架 力学性能 互锁结构 生物活性

PLA 2D-braid PEEK biomedical scaffold mechanical property interlocking structure bioactivity

中文

联合培养

南方科技大学

梁新宇. 聚醚醚酮/聚乳酸复合的生物医用支架研究[D]. 深圳. 哈尔滨工业大学,2020.