Controllable phase transformation of fluoridated calcium phosphate ultrathin coatings for biomedical applications

Ge，Xiang1,2; Zhao，Jianming3; Lu，Xiong4; Li，Zhaoyang5; Wang，Kefeng6; Ren，Fuzeng7; Wang，Menghao8; Wang，Qun9; Qian，Bao10

2020-12-20

10.1016/j.jallcom.2020.155920

JOURNAL OF ALLOYS AND COMPOUNDS   影响因子和分区

0925-8388

Titanium has been widely used in medical implants for hard tissue replacements. Nevertheless, the bioinert innate oxide layer on the titanium implant surface usually makes the implant fail to osseointegrate with the surrounding tissue after surgery. To improve the bioactivity of titanium implants, the deposition of calcium phosphate (CaP) coatings attracts much research interest owing to the excellent bioactivity and biocompatibility of CaP. This work successfully developed a promising synthetic method to prepare uniform fluoridated CaP coatings with ultrathin thicknesses (∼170 nm) and desired phases on acid etched pure titanium (AETi) substrates. A dense ultrathin coating with a dominant phase of fluoridated amorphous CaP (FACP) was obtained by an electrochemical deposition method in galvanostatic mode. After a heat treatment at 600 °C for 3 h in a humid atmosphere, the as-prepared coating was transformed to a coating with a dominant phase of fluoridated hydroxyapatite (FHA). Additionally, the dominant phase of the coating could be transformed from FACP to α-tricalcium phosphate (α-TCP) by a heat treatment at 800 °C for 3 h. Unlike previously reported fluoridated CaP coatings with thicknesses of around several micrometers, the ultrathin thickness could potentially enhance the adhesive strength and ductility of coating. Notably, the fluorine incorporation in the coating could bring in additional benefits such as lower solubility, higher antibacterial activity, and higher adhesive strength. Electrochemical deposition associated with post heat treatment could obtain fluoridated CaP coatings with different desired phases in a controllable manner, which is very important since CaPs with different phases possess different properties and may be suitable for different biomedical applications. This study proposed a promising, simple, and low-cost method which can endow complex-shaped titanium implants with better bioactivity for dental and orthopedic applications.

Electrochemical deposition Fluoridated amorphous calcium phosphate (FACP) Fluoridated hydroxyapatite (FHA) Phase transformation Ultrathin coating α-tricalcium phosphate (α-TCP)

SCI ; EI

英语

其他

20203409088487

Biocompatibility ; Metal implants ; Tissue ; Titanium dioxide ; Hydroxyapatite ; Phase transitions ; Thickness measurement ; Medical applications ; Phosphate coatings ; Heat treatment ; Transmission control protocol ; Electrochemical deposition ; Reduction ; Adhesives

Biological Materials and Tissue Engineering:461.2 ; Immunology:461.9.1 ; Prosthetics:462.4 ; Minerals:482.2 ; Heat Treatment Processes:537.1 ; Metals Corrosion and Protection; Metal Plating:539 ; Protection Methods:539.2.1 ; Data Communication, Equipment and Techniques:722.3 ; Computer Software, Data Handling and Applications:723 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Coating Materials:813.2 ; Mechanical Variables Measurements:943.2

MATERIALS SCIENCE

2-s2.0-85089568532

Scopus

1.Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education,School of Mechanical Engineering,Tianjin University,Tianjin,300354,China
2.Department of Mechanical and Aerospace Engineering,The Hong Kong University of Science and Technology,Clear Water Bay, Kowloon,Hong Kong
3.TCPS Company Limited,Tianjin,300384,China
4.Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China
5.Tianjin Key Laboratory of Composite and Functional Materials,School of Materials Science and Engineering,Tianjin University,Tianjin,300350,China
6.National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610064,China
7.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
8.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
9.College of Life Science and Biotechnology,MianYang Teachers’ College,Mianyang,621006,China
10.Department of Machine Elements and Engineering Design,University of Kassel,Kassel,34125,Germany

Ge，Xiang,Zhao，Jianming,Lu，Xiong,et al. Controllable phase transformation of fluoridated calcium phosphate ultrathin coatings for biomedical applications[J]. JOURNAL OF ALLOYS AND COMPOUNDS,2020,847.

Ge，Xiang.,Zhao，Jianming.,Lu，Xiong.,Li，Zhaoyang.,Wang，Kefeng.,...&Qian，Bao.(2020).Controllable phase transformation of fluoridated calcium phosphate ultrathin coatings for biomedical applications.JOURNAL OF ALLOYS AND COMPOUNDS,847.

Ge，Xiang,et al."Controllable phase transformation of fluoridated calcium phosphate ultrathin coatings for biomedical applications".JOURNAL OF ALLOYS AND COMPOUNDS 847(2020).